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Simple Method for Transformation and Gene Editing in Medicinal Plants.
Journal of Integrative Plant Biology, 2023 Gene editing technologies have ushered in a significant advancement in plant genetics research and molecular breeding. However, a critical challenge hindering the widespread adoption of these technologies is the efficient delivery of gene-editing tools ...
Xue-cheng Cao +6 more
semanticscholar +1 more source
CRISPR/Cas9-gene editing approaches in plant breeding
GM crops & food, 2023 CRISPR/Cas9 gene editing system is recently developed robust genome editing technology for accelerating plant breeding. Various modifications of this editing system have been established for adaptability in plant varieties as well as for its improved ...
Himanshu Saini +4 more
semanticscholar +1 more source
Translational Neurodegeneration, 2022 Background The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition
Hongwon Kim +4 more
doaj +1 more source
Nature Nanotechnology, 2022 Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours for efficient cancer therapy remains challenging.
Di Zhang +10 more
semanticscholar +1 more source
Lipid nanoparticles allow efficient and harmless ex vivo gene editing of human hematopoietic cells
Blood, 2023 Key Points • Electroporation triggers significant cytotoxicity in gene-edited T cells and hematopoietic stem cells.• LNPs as a delivery method for editing reagents dampen cytotoxicity, increasing the yield of ex vivo–edited hematopoietic cells.
V. Vavassori +13 more
semanticscholar +1 more source
Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Experimental and Molecular Medicine, 2020 Regenerative medicine: Protein boosts stem cell generation process Heightened expression of a DNA repair protein improves efficiency when generating induced pluripotent stem cells (iPSCs) for use in regenerative medicine.
Hanseul Park +2 more
doaj +1 more source
Proceedings, 2020 Current antiretroviral therapy efficiently suppresses viral replication but cannot eliminate latent HIV reservoirs. Moreover, the associated high costs, side effects, and drug resistance have stimulated a need for the development of alternative methods ...
Aleksandra Maslennikova +3 more
doaj +1 more source
Translational Neurodegeneration, 2022 Background Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progression of these diseases ...
Hanseul Park +5 more
doaj +1 more source
Gene editing for inflammatory disorders [PDF]
Annals of the Rheumatic Diseases, 2019 Technology for precise and efficient genetic editing is constantly evolving and is now capable of human clinical applications. Autoimmune and inflammatory diseases are chronic, disabling, sometimes life-threatening, conditions that feature heritable components.
David T, Ewart +2 more
openaire +2 more sources
Strategies for mitochondrial gene editing
Computational and Structural Biotechnology Journal, 2021 Mitochondria, as the energy factory of cells, participate in metabolism processes and play a critical role in the maintenance of human life activities. Mitochondria belong to semi-automatic organelles, which have their own genome different from nuclear genome. Mitochondrial DNA (mtDNA) mutations can cause a series of diseases and threaten human health.
Xingbo Yang +4 more
openaire +3 more sources