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Gene Editing, Identity and Benefit [PDF]
The Philosophical Quarterly, 2021 Abstract Some suggest that gene editing human embryos to prevent genetic disorders will be in one respect morally preferable to using genetic selection for the same purpose: gene editing will benefit particular future persons, while genetic selection would merely replace them.
Douglas, T, Devolder, K
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Life, 2021 The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive.
Honghui Li +13 more
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Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas
Scientific Reports, 2022 Gene correction is often referred to as the gold standard for precise gene editing and while CRISPR-Cas systems continue to expand the toolbox for clinically relevant genetic repair, mechanistic hurdles still hinder widespread implementation.
Brett M. Sansbury +5 more
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Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Life, 2022 As a member of the PIKs family, PIK3C3 participates in autophagy and plays a central role in liver function. Several studies demonstrated that the complete suppression of PIK3C3 in mammals can cause hepatomegaly and hepatosteatosis. However, the function
Jing Wang +19 more
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Gene editing and gene regulation with CRISPR [PDF]
Experimental Physiology, 2018 Genome editing enables precise changes to be made in the genome of living cells. The technique was originally developed in the 1980’s but largely limited to use in mice. The discovery that a targeted double stranded break (DSB) at a unique site in the genome, close to the site to be changed, could substantially increase the efficiency of editing ...
Patrick Harrison, Stephen Hart
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The origin of unwanted editing byproducts in gene editing
Acta Biochimica et Biophysica Sinica, 2022 The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subsequently the DNA repair pathways are recruited to generate diverse editing outcomes.
Yin Jianhang, Hu Jiazhi
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Establishment of PCR Identification Method for Pig Blood Type
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveXenotransplantation is an effective way to address the shortage of human organ donors, but it faces serious immune rejection reactions, including hyperacute rejection caused by blood type differences.
WANG Jiaoxiang +8 more
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The Ethics of Germline Gene Editing [PDF]
Journal of Applied Philosophy, 2016 AbstractGermline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development.
Gyngell, Christopher +2 more
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Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan
Veterinary Sciences, 2022 Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal +12 more
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Open Access Indonesian Journal of Medical Reviews, 2021 For thousands of years, humans have felt the need to understand the world around them—and ultimately manipulate it to best serve their needs. There are always ethical questions to address, especially when the manipulation involves the human genome. There is currently an urgent need to actively pursue those conversations as com- mercial gene sequencing ...
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