Results 31 to 40 of about 869,701 (314)
Gene editing for inflammatory disorders [PDF]
Annals of the Rheumatic Diseases, 2019 Technology for precise and efficient genetic editing is constantly evolving and is now capable of human clinical applications. Autoimmune and inflammatory diseases are chronic, disabling, sometimes life-threatening, conditions that feature heritable components.
David T, Ewart +2 more
openaire +2 more sources
Strategies for mitochondrial gene editing
Computational and Structural Biotechnology Journal, 2021 Mitochondria, as the energy factory of cells, participate in metabolism processes and play a critical role in the maintenance of human life activities. Mitochondria belong to semi-automatic organelles, which have their own genome different from nuclear genome. Mitochondrial DNA (mtDNA) mutations can cause a series of diseases and threaten human health.
Xingbo Yang +4 more
openaire +3 more sources
Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing [PDF]
, 2022 Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy.
Luan Wen +10 more
core +1 more source
Endogenous leptin promotes autophagy in EBSS-induced PFCs
Animal Cells and Systems, 2019 Leptin is an important adipokine and plays a vital role in animals. However, the role of leptin in the autophagic response of pig fibroblast cells (PFCs) has not been fully elucidated.
Deling Jiao +10 more
doaj +1 more source
CRISPR-Based Therapeutic Gene Editing for Duchenne Muscular Dystrophy: Advances, Challenges and Perspectives [PDF]
, 2022 Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease arising from loss-of-function mutations in the dystrophin gene and characterized by progressive muscle degeneration, respiratory insufficiency, cardiac failure, and premature death by ...
Hui Yang +9 more
core +1 more source
, 2023 Gene editing allows scientists to modify an organism's DNA with unparalleled precision, utilizing techniques like CRISPR-Cas9. It aids researchers to target specific genes, enhance desirable traits, correct genetic disorders, and develop innovative therapies.
openaire +3 more sources
Proceedings, 2020 Current antiretroviral therapy efficiently suppresses viral replication but cannot eliminate latent HIV reservoirs. Moreover, the associated high costs, side effects, and drug resistance have stimulated a need for the development of alternative methods ...
Aleksandra Maslennikova +3 more
doaj +1 more source
CRISPR Gene Editing in the Kidney [PDF]
American Journal of Kidney Diseases, 2018 CRISPR is a nuclease guidance system that enables rapid and efficient gene editing of specific DNA sequences within genomes. We review applications of CRISPR for the study and treatment of kidney disease. CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies.
Nelly M, Cruz, Benjamin S, Freedman
openaire +2 more sources
Gene Editing: Medicine or enhancement [PDF]
, 2020 In this paper we will discuss the status of gene editing technologies like CRISPR. We will examine whether this technology should be considered a form of enhancement, or if CRISPR is merely a medical technology analogous to many of the common medical ...
Anomaly, Jonathan +2 more
core
Translational Neurodegeneration, 2022 Background Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progression of these diseases ...
Hanseul Park +5 more
doaj +1 more source