Results 31 to 40 of about 8,657,992 (314)
Human Genetics, 2023 Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) gene-editing system (CRISPR-Cas) is a valuable tool for fundamental and applied research applications.
John Hunt +3 more
semanticscholar +1 more source
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Nature Communications, 2021 Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune ...
Tian-Yu Song +15 more
doaj +1 more source
RNA Targeting and Gene Editing Strategies for Transthyretin Amyloidosis
BioDrugs, 2023 Transthyretin (TTR) is a tetrameric protein synthesized primarily by the liver. TTR can misfold into pathogenic ATTR amyloid fibrils that deposit in the nerves and heart, causing a progressive and debilitating polyneuropathy (PN) and life-threatening ...
A. Ioannou, M. Fontana, J. Gillmore
semanticscholar +1 more source
The CRISPR-Cas toolbox and gene editing technologies.
Molecules and Cells, 2021 The emergence of CRISPR-Cas systems has accelerated the development of gene editing technologies, which are widely used in the life sciences. To improve the performance of these systems, workers have engineered and developed a variety of CRISPR-Cas tools
Guanwen Liu +3 more
semanticscholar +1 more source
Gene Editing by Extracellular Vesicles [PDF]
International Journal of Molecular Sciences, 2020 CRISPR/Cas technologies have advanced dramatically in recent years. Many different systems with new properties have been characterized and a plethora of hybrid CRISPR/Cas systems able to modify the epigenome, regulate transcription, and correct mutations in DNA and RNA have been devised.
Dmitry Kostyushev +6 more
openaire +2 more sources
CRISPR-based gene editing technology and its application in microbial engineering
Engineering Microbiology, 2023 Gene editing technology involves the modification of a specific target gene to obtain a new function or phenotype. Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-mediated technologies have provided an efficient ...
Junwei Wei, Yingjun Li
semanticscholar +1 more source
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing
Signal Transduction and Targeted Therapy, 2022 Dear Editor, Male infertility is a multifactorial heterogeneous pathological condition affecting ∼7% of men. Nonobstructive azoospermia (NOA) is one of the most severe male reproductive diseases and occurs in ∼1% of men of reproductive age.
Min Chen +11 more
semanticscholar +1 more source
Gene Editing and Journal Editing [PDF]
The New Bioethics, 2018 Editorial for special issue of The New Bioethics dedicated to the ethics of genomic ...
openaire +1 more source
Optimizing 5’UTRs for mRNA-delivered gene editing using deep learning
bioRxiv, 2023 mRNA therapeutics are revolutionizing the pharmaceutical industry, but methods to optimize the primary sequence for increased expression are still lacking. Here, we design 5’UTRs for efficient mRNA translation using deep learning.
Sebastian Castillo Hair +6 more
semanticscholar +1 more source
Efficient generation of brain organoids using magnetized gold nanoparticles
Scientific Reports, 2023 Brain organoids, which are three-dimensional cell culture models, have the ability to mimic certain structural and functional aspects of the human brain.
Hongwon Kim +3 more
doaj +1 more source