Results 41 to 50 of about 869,701 (314)

Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41

mBio, 2022
Previous studies suggest that short peptides from the heptad repeat 2 (HR2) domain of gp41 expressed on the cell surface are more potent inhibitors of HIV-1 entry than soluble analogs.
Alexandra Maslennikova, Natalia Kruglova, Svetlana Kalinichenko, Dmitriy Komkov, Mikhail Shepelev, Dmitriy Golubev, Andrei Siniavin, Andrei Vzorov, Alexander Filatov, Dmitriy Mazurov   +9 more
doaj   +1 more source

Gene editing

Postępy Biochemii, 2018
Development of the gene engineering techniques has raised worries that they will be used for construction of organism endangering humansand environment. In 1975 at the Asilomar conference, geneticists from many countries decided that genetic engineering brings more benefitsthan threats. In last years a new CRISPR-Cas technique emerged .
openaire   +3 more sources

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing [PDF]

, 2023
openLa distrofia muscolare di Duchenne (DMD) è una malattia genetica rara e mortale, causata dalla mancanza di distrofina. Le mutazioni nel gene DMD, localizzato nel cromosoma X, sono trasmesse in modo recessivo legato al sesso; in particolare, una ...
DE ANTONI, NOEMI
core  

Gene Editing for the Treatment of Primary Immunodeficiency Diseases [PDF]

, 2021
With conventional treatments for primary immunodeficiency diseases (PIDs), such as allogeneic stem cell transplantation or autologous gene therapy, still facing important challenges, the rapid development of genome editing technologies to more accurately
Cavazza A., Rai R., Thrasher A. J.
core   +1 more source

Functional characterization of tumor-specific CRISPR-directed gene editing as a combinatorial therapy for the treatment of solid tumors

Molecular Therapy: Oncology
As we pursue clinical applications for CRISPR-directed gene editing in overcoming resistance to anticancer drugs, we have focused on genetic disruption of the transcription factor, NRF2, a master regulator of cellular stress and detoxification. The level
Kelly H. Banas, Pawel A. Bialk, Natalia Rivera-Torres, Katelynn Owens, Tori N. Reiner, Kristen M. Pisarcik, Nicole Haas, Emily Gielda, Komal Khan, Krishna Priya Narra, Eric B. Kmiec   +10 more
doaj   +1 more source

Protecting women by moderating men? Gene line editing in the case of the MAOA gene and social markers [PDF]

In this thesis, it is argued that there are serious reasons to consider gene editing to prevent unusually violent males from existing. Violence disproportionately impacts women, girls and sexual minorities perpetrated largely by cisgender non intersex ...
Emerson-Keeler, Rebecca
core   +2 more sources

Gene editing CRISPR/Cas9 system for producing cows with hypoallergenic milk on the background of a beta-lactoglobulin gene knockout [PDF]

E3S Web of Conferences, 2020
Beta-lactoglobulin is the main allergen of cow’s milk. Modern approaches to reducing the allergenicity of milk require significant costs for its fermentation. An alternative approach could be the creation of productive breeds with a knockout for the gene
Silaeva Yulia Yu., Kubekina Marina V., Bruter Alexandra V., Isaeva Albina G., Koshchaev Andrey G.   +4 more
doaj   +1 more source

Bioethical considerations on gene editing for plant breeding techniques: a case-study. [PDF]

, 2022
reservedFin dalla sua origine le applicazioni di ingegneria genetica hanno suscitato polemiche a causa della possibile influenza negativa di questi organismi o dei loro derivati sulla salute, sull'ambiente e sulla biodiversità.
SCUDELLER, ANNA TERESA
core  

Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing [PDF]

, 2007
Wittkop T, Baumbach J, Lobo FP, Rahmann S. Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing. BMC Bioinformatics.
Wittkop, Tobias, Tobias Wittkop, Baumbach Jan, Lobo Francisco P, Sven Rahmann, Francisco P Lobo, Rahmann Sven, Jan Baumbach, Baumbach, Jan, Wittkop Tobias, Lobo, Francisco P., Rahmann, Sven   +11 more
core   +2 more sources

Target choice and exon skipping regulate CRISPR-directed gene editing of NRF2 in head/neck and esophageal cancer cells

Molecular Therapy: Oncology
Head and neck cancer (HNC) is the seventh most diagnosed cancer, with a predicted 30% increase annually by 2030. Conventional treatment is often combinatorial involving chemotherapy and radiation therapy, immunotherapy, and surgery, but over time ...
Natalia Rivera-Torres, Lauren E. Skelly, John A. Rogowskyj, Guadalupe Aguilar, Kelly Banas, Pawel Bialk, Eric B. Kmiec   +6 more
doaj   +1 more source