Results 61 to 70 of about 3,565,977 (300)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Can graph-cutting improve microarray gene expression reconstructions? [PDF]
, 2008 Microarrays produce high-resolution image data that are, unfortunately, permeated with a great deal of “noise” that must be removed for precision purposes. This paper presents a technique for such a removal process. On completion of this non-trivial task,
Liu, X +4 more
core +5 more sources
Epigenetic Drift and the Generational Limit of Serial Somatic Cell Nuclear Transfer in Pigs
AnimalsSomatic cell nuclear transfer (SCNT) in pigs has been a widely used technique for producing gene-edited pigs for biomedical research, yet its wide-spread application through serial cloning remains markedly limited.
Na Cheng +6 more
doaj +1 more source
The hallmarks of dietary intervention-resilient gut microbiome
npj Biofilms and Microbiomes, 2022 Maintaining equilibrium of the gut microbiome is crucial for human health. Diet represents an important and generally accessible natural channel of controlling the nutrients supply to the intestinal microorganisms.
Natalia S. Klimenko +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9 [PDF]
, 2015 CRISPR/Cas9 technologies have been employed for genome editing to achieve gene knockouts and knock-ins in somatic cells. Similarly, certain endogenous genes have been tagged with fluorescent proteins. Often, the detection of tagged proteins requires high
Rojas-Fernandez, Alejandro +5 more
core +1 more source
Generation of RAG2 Knockout Immune-Deficient Miniature Pigs
AnimalsRecombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared to ...
Jing Wang +8 more
doaj +1 more source