Results 71 to 80 of about 869,701 (314)
Development of CRISPR-Cas genome and epigenome engineering tools towards retinal degenerations [PDF]
, 2023 Inherited retinal diseases (IRDs) are a diverse family of disorders caused by genetic mutations that lead to dysfunction and death of cells in the outer retina.
Kantor, Ariel
core +1 more source
Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig
Shiyan dongwu yu bijiao yixueObjective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai +10 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Biological ResearchBackground Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal +17 more
doaj +1 more source
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Viruses, 2022 So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes.
Svetlana Kalinichenko +2 more
doaj +1 more source
Nature Methods, 2013 Targeted gene modification can be guided by programmable RNA in bacteria, zebrafish and mammalian cells.
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
, 2012 Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie +5 more
core +1 more source
From amputations to antibiotics: A future beyond "hacksaw" gene editing (Editorial) [PDF]
, 2022 Nuclease-based gene editing could be likened to hacksaw surgery upon the genome. In fact, two recent papers have reiterated the untoward consequences of CRISPR-Cas-mediated double-stranded breaks (DSBs): p53-induced toxicity and effects upon the gross ...
Morris, Kevin V, Scott, Tristan
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source