Results 81 to 90 of about 3,565,977 (300)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

, 2023
openLa distrofia muscolare di Duchenne (DMD) è una malattia genetica rara e mortale, causata dalla mancanza di distrofina. Le mutazioni nel gene DMD, localizzato nel cromosoma X, sono trasmesse in modo recessivo legato al sesso; in particolare, una ...
DE ANTONI, NOEMI
core  

Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing

, 2022
Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy.
Luan Wen, Ruonan Dong, Laura Saunders, Peter X. Ma, Dongshan Yang, Y. Eugene Chen, Kemao Xiu, Jinxue Ruan, Jie Xu, Jun Song, Jifeng Zhang   +10 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Genome-wide analysis of soybean MLPs reveals evolutionary and structural insights into drought, salt stress and ABA responses

BMC Plant Biology
The major latex protein (MLP) gene family, which is part of the Bet v 1 superfamily, is known for its roles in plant development and stress responses. However, the MLP gene family in soybean (Glycine max) remains insufficiently characterized.
Xiaocen Ma, Qing Yu, Qi Wang, Yixuan Li, Yongnuo Yuan, Heng Liu, Siyu Chen, Wei Wang   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

The field of gene editing is rapidly developing, particularly with advancements in gene editor technologies. Prime editing has been a significant breakthrough in gene editing, allowing precise, targeted correction of all types of DNA mutation, including ...
Satyapertiwi, Dwiantari
core   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie, Schnaufer, Achim; id_orcid, Stuart, Kenneth, Carnes, Jason, Lerch, Melissa, Guo, Xuemin   +5 more
core   +1 more source

CRISPR-Based Therapeutic Gene Editing for Duchenne Muscular Dystrophy: Advances, Challenges and Perspectives

, 2022
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease arising from loss-of-function mutations in the dystrophin gene and characterized by progressive muscle degeneration, respiratory insufficiency, cardiac failure, and premature death by ...
Hui Yang, Li, Haisen, Guoling Li, Guofang Chen, Tingyi Wei, Chen, Guofang, Li, Guoling, Wei, Tingyi, Haisen Li, Yang, Hui   +9 more
core   +1 more source

Therapeutic Gene Editing for Hemoglobinopathies.

Mediterranean journal of hematology and infectious diseases
In the last ten years, a consistent number of clinical studies have evaluated different gene approaches for the treatment of patients with sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT). Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding β ...
Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini   +2 more
openaire   +3 more sources