Results 51 to 60 of about 3,565,977 (300)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Preliminary Study on Construction Method of Type 1 Diabetes Model in Banna Miniature Pig

Shiyan dongwu yu bijiao yixue
Objective To construct a Type 1 diabetes model in miniature pigs and explore postoperative care strategies for effectively prolonging the survival time of the model pigs. Methods Seven Banna miniature pigs were selected for pancreatectomy.
LIU Kai, HU Yuqi, GENG Yatian, CHENG Wenjie, WANG Jing, WEI Taiyun, ZHAO Hongfang, LI Jiayu, JIAO Deling, ZHAO Hongye, WEI Hongjiang   +10 more
doaj   +1 more source

Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

Nature Communications, 2022
Prime editors can mediate all twelve types of base substitutions and small insertions or deletions in living cells but its efficiency remains low. Here the authors introduce same-sense mutations into pegRNAs to increase base-editing efficiency and the ...
Xiaosa Li, Lina Zhou, Bao-Qing Gao, Guangye Li, Xiao Wang, Ying Wang, Jia Wei, Wenyan Han, Zixian Wang, Jifang Li, Runze Gao, Junjie Zhu, Wenchao Xu, Jing Wu, Bei Yang, Xiaodong Sun, Li Yang, Jia Chen   +17 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model

Biological Research
Background Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme body weight adversely affects reproductive functions. Leptin is a well-known adipokine that serves as an endocrine signal
Muhammad Ameen Jamal, Yixiao Cheng, Deling Jiao, Wen Cheng, Di Zou, Xia Wang, Taiyun Wei, Jianxiong Guo, Kaixiang Xu, Heng Zhao, Shaoxia Pu, Chang Yang, Yubo Qing, Baoyu Jia, Honghui Li, Rusong Zhao, Hong-Ye Zhao, Hong-Jiang Wei   +17 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing [PDF]

, 2007
Wittkop T, Baumbach J, Lobo FP, Rahmann S. Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing. BMC Bioinformatics.
Wittkop, Tobias, Tobias Wittkop, Baumbach Jan, Lobo Francisco P, Sven Rahmann, Francisco P Lobo, Rahmann Sven, Jan Baumbach, Baumbach, Jan, Wittkop Tobias, Lobo, Francisco P., Rahmann, Sven   +11 more
core   +1 more source

Gene editing.

, 2022
A) Schematic representation of CRISPR/Cas9 mediated gene editing. Gene-edited coding sequence and predicted translation are shown. B) ssODN repair template used during CIRSPR/Cas9 gene editing to evoke HDR mediates double strand break repair, fixing the ...
Lena Arévalo (8148903), Simon Schneider (749180), Isabelle Sophie Neumann (12969420), Hubert Schorle (15757), Gina Esther Merges (12969414), Franka Enow Oben (12969417)   +5 more
core   +1 more source

HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread

Viruses, 2022
So far, only two retroviruses, human immunodeficiency virus (HIV) (type 1 and 2) and human T-cell lymphotropic virus type 1 (HTLV-1), have been recognized as pathogenic for humans. Both viruses mainly infect CD4+ T lymphocytes.
Svetlana Kalinichenko, Dmitriy Komkov, Dmitriy Mazurov   +2 more
doaj   +1 more source

Gene Editing for the Treatment of Hypercholesterolemia

Current Atherosclerosis Reports
Abstract Purpose of Review Here, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can lower plasma low-density lipoprotein (LDL)-cholesterol levels to subsequently reduce atherosclerotic cardiovascular disease risk. Recent Findings
Hoekstra, M., Eck, M. van
openaire   +3 more sources