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Germline Gene Editing: The Gender Issues [PDF]
, 2023 Human germline gene editing constitutes an extremely promising technology; at the same time, however, it raises remarkable ethical, legal, and social issues.
De Miguel Beriain, Iñigo +2 more
core +1 more source
Gene Editing and Journal Editing [PDF]
The New Bioethics, 2018 Editorial for special issue of The New Bioethics dedicated to the ethics of genomic ...
openaire +1 more source
Gene regulatory and gene editing tools and their applications for retinal diseases and neuroprotection: From proof-of-concept to clinical trial. [PDF]
, 2022 Gene editing and gene regulatory fields are continuously developing new and safer tools that move beyond the initial CRISPR/Cas9 technology. As more advanced applications are emerging, it becomes crucial to understand and establish more complex gene ...
Ahmadian, Mehri +9 more
core +1 more source
, 2022 A) Schematic representation of CRISPR/Cas9 mediated gene editing. Gene-edited coding sequence and predicted translation are shown. B) ssODN repair template used during CIRSPR/Cas9 gene editing to evoke HDR mediates double strand break repair, fixing the ...
Lena Arévalo (8148903) +5 more
core +1 more source
Efficient generation of brain organoids using magnetized gold nanoparticles
Scientific Reports, 2023 Brain organoids, which are three-dimensional cell culture models, have the ability to mimic certain structural and functional aspects of the human brain.
Hongwon Kim +3 more
doaj +1 more source
CRISPR/Cas to enhance gene expression for crop trait improvement by editing miRNAs targets. [PDF]
, 2023 Article states that gene editing tools such as CRISPR/Cas9 are often thought of as a means to prevent gene expression; however, a more subtle and yet powerful approach is the enhancement of gene expression by precise deletion of repressor sites within a ...
Reis, Rodrigo S. +3 more
core +1 more source
Translational Neurodegeneration, 2022 Background The ε4 allele of apolipoprotein E (APOE ε4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD), associated with amyloid pathogenesis. However, it is not clear how APOE ε4 accelerates amyloid-beta (Aβ) deposition
Hongwon Kim +4 more
doaj +1 more source
Identification of novel components of Trypanosoma brucei editosomes [PDF]
, 2003 The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid +6 more
core +1 more source
He Jiankui´s gene-editing experiment and the non-identity problem [PDF]
, 2021 Genetic engineering has been a topic of discussion for over 50 years, but it is only recently that gene editing has become a reality. CRISPR biotechnologies have made gene editing much safer, precise and feasible.
Julian Savulescu +4 more
core +2 more sources
Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Experimental and Molecular Medicine, 2020 Regenerative medicine: Protein boosts stem cell generation process Heightened expression of a DNA repair protein improves efficiency when generating induced pluripotent stem cells (iPSCs) for use in regenerative medicine.
Hanseul Park +2 more
doaj +1 more source