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The Ethics of Germline Gene Editing [PDF]

Journal of Applied Philosophy, 2016
AbstractGermline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development.
Gyngell, Christopher, Douglas, Thomas, Savulescu, Julian   +2 more
openaire   +3 more sources

The origin of unwanted editing byproducts in gene editing

Acta Biochimica et Biophysica Sinica, 2022
The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subsequently the DNA repair pathways are recruited to generate diverse editing outcomes.
Yin Jianhang, Hu Jiazhi
openaire   +4 more sources

Alternative splicing and extensive RNA editing of human TPH2 transcripts. [PDF]

, 2010
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT.
Bondy, Brigitta, Bondy, B., Baghai Thomas C., Brigitta Bondy, Peter Zill, Zill, P., Schüle Cornelius, Hammer, P., Grohmann Maik, Büttner, A., Walther Maria, Priller, Josef, Hammer Paul, Baghai, Thomas C., Maik Grohmann, Wolfgang Eisenmenger, Baghai, T., Priller Josef, Josef Priller, Walther, D.J., Eisenmenger, Wolfgang, Bader, Michael, Zill, Peter, Paul Hammer, Hammer, Paul, Rupprecht Rainer, Büttner, Andreas, Michael Bader, Andreas Büttner, Diego J Walther, Cornelius Schüle, Paulmann, Nils, Zill Peter, Bader Michael, Eisenmenger, W., Schüle, Cornelius, Maria Walther, Rainer Rupprecht, Thomas C Baghai, Paulmann Nils, Schuele, C., Walther, Diego J., Rupprecht, R., Nils Paulmann, Baghai, T.C., Eisenmenger Wolfgang, Walther, Maria, Grohmann, M., Bondy Brigitta, Walther Diego J., Bader, M., Priller, J., Paulmann, N., Büttner Andreas, Walther, M., Grohmann, Maik, Rupprecht, Rainer, Schüle, C., Walther, D., Buettner, A.   +59 more
core   +1 more source

Gene Editing of Primary Rhesus Macaque B Cells

, 2023
B cells and their progeny are the sources of highly expressed antibodies. Their high protein expression capabilities together with their abundance, easy accessibility via peripheral blood, and amenability to simple adoptive transfers have made them an ...
Nussenzweig, Michel C., Nishimura, Yoshiaki, Hartweger, Harald, Gautam, Rajeev, Yao, Kai-Hui, Martin, Malcolm A., Jankovic, Mila, Schmidt, Fabian, Escolano, Amelia   +8 more
core   +1 more source

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

Gene Editing: Medicine or enhancement [PDF]

, 2020
In this paper we will discuss the status of gene editing technologies like CRISPR. We will examine whether this technology should be considered a form of enhancement, or if CRISPR is merely a medical technology analogous to many of the common medical ...
Anomaly, Jonathan, Alonso Fernández, Marcos, Savulescu, Julian   +2 more
core   +1 more source

Using Gene Editing Strategies for Wheat Improvement [PDF]

, 2023
Despite wheat’s global importance, it has trailed behind the other major cereals regarding genomic tools and resources as well as gene transformation.
Camerlengo, Francesco, Francesco Camerlengo, Mark A. Smedley, Sadiye Hayta, Smedley, Mark A., Hayta, Sadiye, Domenica Nigro, Nigro, Domenica   +7 more
core   +1 more source

Germline Gene Editing: The Gender Issues [PDF]

, 2023
Human germline gene editing constitutes an extremely promising technology; at the same time, however, it raises remarkable ethical, legal, and social issues.
De Miguel Beriain, Iñigo, Payán Ellacuria, Ekain, Sanz Echevarría, María Begoña   +2 more
core   +1 more source

Protecting women by moderating men? Gene line editing in the case of the MAOA gene and social markers [PDF]

In this thesis, it is argued that there are serious reasons to consider gene editing to prevent unusually violent males from existing. Violence disproportionately impacts women, girls and sexual minorities perpetrated largely by cisgender non intersex ...
Emerson-Keeler, Rebecca
core   +1 more source

Gene editing and gene drive on livestock: a bioethical analysis

, 2022
reservedCRISPR-Cas9 è un’innovativa tecnica di gene editing, nota anche come “taglia e cuci” del DNA. Questa tecnica è stata sviluppata nel 2012 dalle due ricercatrici Emmanuelle Charpentier e Jennifer Anne Doudna e, grazie alla sua rilevanza ...
TOSETTO, GIULIA
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