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The Ethics of Germline Gene Editing [PDF]
Journal of Applied Philosophy, 2016 AbstractGermline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development.
Gyngell, Christopher +2 more
openaire +3 more sources
Therapeutic in vivo delivery of gene editing agents
Cell, 2022 Summary In vivo gene editing therapies offer the potential to treat the root causes of many genetic diseases. Realizing the promise of therapeutic in vivo gene editing requires the ability to safely and efficiently deliver gene editing agents to relevant
Aditya Raguram +2 more
semanticscholar +1 more source
Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan
Veterinary Sciences, 2022 Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in ...
Muhammad Ameen Jamal +12 more
doaj +1 more source
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer
Molecular Cancer, 2022 Clustered regularly interspaced short palindromic repeats (CRISPR) system provides adaptive immunity against plasmids and phages in prokaryotes. This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated ...
Si-wei Wang +9 more
semanticscholar +1 more source
Nature Nanotechnology, 2020 CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that
Qiang Cheng +5 more
semanticscholar +1 more source
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
Molecular Cancer, 2022 Chimeric Antigen Receptor (CAR) T-cells represent a breakthrough in personalized cancer therapy. In this strategy, synthetic receptors comprised of antigen recognition, signaling, and costimulatory domains are used to reprogram T-cells to target tumor ...
Alexander J Dimitri +2 more
semanticscholar +1 more source
Application of CRISPR/Cas9-mediated gene editing for abiotic stress management in crop plants
Frontiers in Plant Science, 2023 Abiotic stresses, including drought, salinity, cold, heat, and heavy metals, extensively reducing global agricultural production. Traditional breeding approaches and transgenic technology have been widely used to mitigate the risks of these environmental
M. Kumar +6 more
semanticscholar +1 more source
Nature Materials, 2021 Endosomal escape remains a fundamental barrier hindering the advancement of nucleic acid therapeutics. Taking inspiration from natural phospholipids that comprise biological membranes, we report the combinatorial synthesis of multi-tailed ionizable ...
Shuai Liu +6 more
semanticscholar +1 more source
An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity
Nature Chemical Biology, 2023 Wu, Liu, Zou et al. report an engineered hypercompact AsCas12f system, enAsCas12f, for robust and faithful genome editing in human cells. Cryo-EM study validates the engineering strategy and reveals dimerization-based substrate recognition by AsCas12f ...
Tong Wu +7 more
semanticscholar +1 more source
Open Access Indonesian Journal of Medical Reviews, 2021 For thousands of years, humans have felt the need to understand the world around them—and ultimately manipulate it to best serve their needs. There are always ethical questions to address, especially when the manipulation involves the human genome. There is currently an urgent need to actively pursue those conversations as com- mercial gene sequencing ...
openaire +2 more sources