Results 41 to 50 of about 4,580,472 (190)
On editability of feature-based design [PDF]
Computer-Aided Design, 1995 Techniques needed for editing generative designs are presented. When a feature is edited, all features attached later must be re-evaluated to satisfy the required constraints and shape references in the initial design. We describe name matching techniques that support the design reevaluation procedure.
Chen, Xiangping, Hoffmann, Christoph M.
openaire +2 more sources
Precise genome editing with base editors
Medical Review, 2023 Single-nucleotide variants account for about half of known pathogenic genetic variants in human. Genome editing strategies by reversing pathogenic point mutations with minimum side effects have great therapeutic potential and are now being actively ...
Liu Hongcai +3 more
doaj +1 more source
Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice
Frontiers in Plant Science, 2022 Recently developed base editors provide a powerful tool for plant research and crop improvement. Although a number of different deaminases and Cas proteins have been used to improve base editors the editing efficiency, and editing window are still not ...
Chunjie Wei +8 more
doaj +1 more source
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
, 2007 RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
core +1 more source
Base Editing in Plants: Applications, Challenges, and Future Prospects
Frontiers in Plant Science, 2021 The ability to create targeted modifications in the genomes of plants using genome editing technologies has revolutionized research in crop improvement in the current dispensation of molecular biology.
Mawuli K. Azameti +2 more
doaj +1 more source
Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics, 2020 ACL ...
Hayate Iso, Chao Qiao, Hang Li
openaire +3 more sources
Overcoming Multidrug Resistance by Base-Editing-Induced Codon Mutation
, 2023 Multidrug resistance (MDR) is the main obstacle in cancer chemotherapy. ATP binding cassette (ABC) transporters on the MDR cell membrane can transport a wide range of antitumor drugs out of cells, which is one of the main causes of MDR.
Bang-Ce Ye (117072) +7 more
core +1 more source
Frame-Based Editing: Combining the Best of Blocks and Text Programming [PDF]
, 2016 Editing program code as text has several major weaknesses: syntax errors (such as mismatched braces) interrupt programmer flow and make automated tool support harder, boilerplate code templates have to be typed out, and programmers are responsible for ...
Neil C. C. Brown +7 more
core +1 more source
Base editing of an α-globin enhancer to treat β-thalassemia
, 2022 reservedGene therapy is the new frontier of medicine, based on modifying the gene material in cells to cure diseases. This strategy comes from the discovery of clustered regularly interspaced short pal-indromic repeats (CRISPR)-Cas system, which has ...
GENTILE, GAIA
core
Base Editing–Enabled Technologies and Multiplex Genome Editing [PDF]
Base editing is a precision genome editing technology that enables targeted single-nucleotide changes without requiring double-strand DNA breaks. This dissertation presents several distinct advances in multiplex base editing and base editing–enabled ...
Volf, Verena
core +4 more sources