Results 21 to 30 of about 515,050 (293)

Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer

Genomics, Proteomics & Bioinformatics, 2023
Base editing technology is being increasingly applied in genome engineering, but the current strategy for designing guide RNAs (gRNAs) relies substantially on empirical experience rather than a dependable and efficient in silico design.
Gongchen Zhang, Chenyu Zhu, Xiaohan Chen, Jifang Yan, Dongyu Xue, Zixuan Wei, Guohui Chuai, Qi Liu   +7 more
doaj   +1 more source

Image-based material editing [PDF]

ACM Transactions on Graphics, 2005
Photo editing software allows digital images to be blurred, warped or re-colored at the touch of a button. However, it is not currently possible to change the material appearance of an object except by painstakingly painting over the appropriate pixels. Here we present a method for automatically replacing one material with another, completely different
Erum Arif Khan, Erik Reinhard, Roland W. Fleming, Heinrich H. Bülthoff   +3 more
openaire   +7 more sources

Advances and Applications of Plant Base Editing Technologies. [PDF]

Int J Mol Sci
Base editing represents a major breakthrough in the field of genome editing in recent years. By fusing deaminases with the CRISPR/Cas system, it enables precise single-base modifications of DNA.
Peng H, Li J, Sun K, Tang H, Huang W, Li X, Wang S, Ding K, Han Z, Li Z, Xu L, Wang K.   +11 more
europepmc   +2 more sources

Unbranched rod-like RNA is required for RNA editing of hepatitis delta virus genotype 2 and genotype 4

Virus Research, 2023
RNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of ...
Chao-Wei Hsu, Hsueh-Ying Hsu, Chien-Hung Chen, Mei Chao   +3 more
doaj   +1 more source

And now, evidence based editing [PDF]

BMJ, 1995
The third congress on peer review will be in Prague in September 1997 Peer review is slow, expensive, prone to bias, corruptible, and possibly anti-innovatory.1 Yet it is central not only to the production of scientific journals but to all of science. Like democracy it may be an imperfect process, but it is better than the alternatives.2 3 4 Or is it?
R, Smith, D, Rennie
openaire   +2 more sources

PAM-expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G base editors for programmable base editing in mycobacteria

, 2021
New therapeutic strategies for rapid and effective treatment of tuberculosis are highly desirable, and their development can be drastically accelerated by facile genetic manipulation methods in Mycobacterium tuberculosis.
Wei-Xiao, Wang, Xingxu, Huang, Quanjiang, Ji, Wei, Chen, Weizhong, Chen, Xia, Zhang, Hongyuan, Zhang, Yifei, Zhang   +7 more
core   +1 more source

Development of a Simple and Quick Method to Assess Base Editing in Human Cells

Molecular Therapy: Nucleic Acids, 2020
Base editing is a form of genome editing that can directly convert a single base (C or A) to another base (T or G), which is of great potential in biomedical applications.
Xiujuan Lv, Kairui Qiu, Tianxiang Tu, Xiaoxue He, Yuchen Peng, Jinbin Ye, Junhao Fu, Ruzhi Deng, Yuqin Wang, Jinyu Wu, Changbao Liu, Junzhao Zhao, Feng Gu   +12 more
doaj   +1 more source

Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors

Frontiers in Genome Editing, 2022
Base editors (BEs) are genome editing agents that install point mutations with high efficiency and specificity. Due to their reliance on uracil and inosine DNA damage intermediates (rather than double-strand DNA breaks, or DSBs), it has been hypothesized
Cameron A. Burnett, Ashley T. Wong, Carlos A. Vasquez, Colleen A. McHugh, Gene W. Yeo, Gene W. Yeo, Alexis C. Komor   +6 more
doaj   +1 more source

Fact-based Text Editing [PDF]

Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics, 2020
ACL ...
Hayate Iso, Chao Qiao, Hang Li
openaire   +2 more sources

Overcoming Multidrug Resistance by Base-Editing-Induced Codon Mutation

, 2023
Multidrug resistance (MDR) is the main obstacle in cancer chemotherapy. ATP binding cassette (ABC) transporters on the MDR cell membrane can transport a wide range of antitumor drugs out of cells, which is one of the main causes of MDR.
Bang-Ce Ye (117072), Bin-Cheng Yin (259643), Jian Xiang, Bin-Cheng Yin, He-Hua Zhang (15356489), Bang-Ce Ye, Jian Xiang (1580053), He-Hua Zhang   +7 more
core   +1 more source