Results 21 to 30 of about 1,037,544 (299)
Development of a Simple and Quick Method to Assess Base Editing in Human Cells
Molecular Therapy: Nucleic Acids, 2020 Base editing is a form of genome editing that can directly convert a single base (C or A) to another base (T or G), which is of great potential in biomedical applications.
Xiujuan Lv +12 more
doaj +1 more source
Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors
Frontiers in Genome Editing, 2022 Base editors (BEs) are genome editing agents that install point mutations with high efficiency and specificity. Due to their reliance on uracil and inosine DNA damage intermediates (rather than double-strand DNA breaks, or DSBs), it has been hypothesized
Cameron A. Burnett +6 more
doaj +1 more source
A review of application of base editing for the treatment of inner ear disorders
Journal of Bio-X Research, 2020 . The development of applications for the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9) system has increased greatly in recent years, especially in the area of gene therapy by efficient in vivo ...
Xingle Zhao +4 more
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Base editing the mammalian genome [PDF]
Methods, 2019 Base editing is a powerful technology that enables programmable conversion of single nucleotides in the mammalian genome. Base editors consist of a partially active Cas9 nuclease (Cas9D10A) tethered to a natural or synthetic DNA modifying enzyme.
Emma M, Schatoff +2 more
openaire +2 more sources
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
Research progress in gene editing technology
Frontiers in Bioscience-Landmark, 2021 As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been
Sheng Huang +9 more
doaj +1 more source
Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics, 2020 ACL ...
Hayate Iso, Chao Qiao, Hang Li
openaire +2 more sources
Genome Biology, 2020 We present a base editing system, in which base editors are attached to different sites of sgRNA scaffold (sgBE). Each independent sgBE has its own specific editing pattern for a given target site.
Yanhong Wang +9 more
doaj +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik +3 more
core +2 more sources
Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver [PDF]
, 2014 BackgroundRNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of
Billing, Anja M +11 more
core +3 more sources