Results 11 to 20 of about 4,580,472 (190)
Be-dataHIVE: a base editing database [PDF]
BMC BioinformaticsBase editing is an enhanced gene editing approach that enables the precise transformation of single nucleotides and has the potential to cure rare diseases.
Lucas Schneider, Peter Minary
doaj +6 more sources
Base editing and prime editing in laboratory animals [PDF]
Laboratory Animals, 2021 Genome editing by programmable RNA-dependent Cas endonucleases has revolutionised the field of genome engineering, achieving targeted genomic change at unprecedented efficiencies with considerable application in laboratory animal research. Despite its ease of use and wide application, there remain concerns about the precision of this technology and a ...
Federico Caso, Benjamin Davies
openaire +4 more sources
CRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis [PDF]
MycologyBase editors are regarded as reliable and precise editing tools due to their ability to efficiently and accurately modify the target genes without inducing double-strand breaks (DSBs).
Yushi Fu +6 more
doaj +2 more sources
Base editing reversal of radiation sensitivity in NHEJ1 immunodeficiencyReversal of radiation sensitivity through base editing [PDF]
Journal of Human ImmunityThe cutting and joining of DNA is a key step in immune cell development, but inherited errors in this process can cause individuals to be born without functioning immune systems.
Renuka Kadirkamanathan +6 more
doaj +2 more sources
Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts
Animals, 2021 Multiplex genome editing may induce genotoxicity and chromosomal rearrangements due to double-strand DNA breaks at multiple loci simultaneously induced by programmable nucleases, including CRISPR/Cas9. However, recently developed base-editing systems can
Soo-Young Yum, Goo Jang, Okjae Koo
doaj +2 more sources
CRISPR-Cas9-Based Genome Editing and Cytidine Base Editing in Acinetobacter baumannii
STAR Protocols, 2020 Summary: Infections caused by drug-resistant Acinetobacter baumannii have posed a serious threat to global public health. However, genetic manipulation methods, the primary way to study pathogenesis and drug-resistance mechanisms, remain time consuming ...
Yu Wang, Zhipeng Wang, Quanjiang Ji
doaj +3 more sources
A hit for base editing: treatment of developmental epilepsy in a mouse model [PDF]
The Journal of Clinical InvestigationCRISPR/Cas9 base editing holds the potential to treat disease caused by single-nucleotide variants. In contrast with conventional CRISPR/Cas9 approaches, base editing enzymatically induces precise DNA alterations and can directly correct disease-causing ...
Sophie F. Hill, Ethan M. Goldberg
doaj +2 more sources
Developing Collaborative XML Editing Systems [PDF]
, 2007 In many areas the eXtensible Mark-up Language (XML) is becoming the standard exchange and data format. More and more applications not only support XML as an exchange format but also use it as their data model or default file format for graphic, text and ...
Gerlicher, Ansgar Robert Sandy
core +5 more sources
Advances and Applications of Plant Base Editing Technologies. [PDF]
Int J Mol SciBase editing represents a major breakthrough in the field of genome editing in recent years. By fusing deaminases with the CRISPR/Cas system, it enables precise single-base modifications of DNA.
Peng H +11 more
europepmc +2 more sources