A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells. [PDF]
Sci Rep, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Ligasová A +3 more
europepmc +2 more sources
Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.
PLoS Pathogens, 2009 The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of the ...
Iñigo Narvaiza +7 more
doaj +4 more sources
The APOBEC3B cytidine deaminase is an adenovirus restriction factor. [PDF]
PLoS Pathog, 2023 Human adenoviruses (HAdVs) are a large family of DNA viruses counting more than a hundred strains divided into seven species (A to G). HAdVs induce respiratory tract infections, gastroenteritis and conjunctivitis. APOBEC3B is a cytidine deaminase that restricts several DNA viruses. APOBEC3B is also implicated in numerous cancers where it is responsible
Lejeune N +9 more
europepmc +5 more sources
Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. [PDF]
Commun BiolCytidine deaminase (CDA) converts cytidine and deoxycytidine into uridine and deoxyuridine as part of the pyrimidine salvage pathway. Elevated levels of CDA are found in pancreatic tumors and associated with chemoresistance. Recent evidence suggests that
Frances A +15 more
europepmc +2 more sources
APOBEC3A is a prominent cytidine deaminase in breast cancer.
PLoS Genetics, 2019 APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez +7 more
doaj +3 more sources
Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
doaj +1 more source
Partial purification of cytidine deaminase from protoscoleces of Echinococcus granulosus [PDF]
Kirkuk Journal of Science, 2015 Cytidine deaminase (EC 3.5.4.5) has been partially purified from protoscoleces of Echinococcus granulosus by gel filteration chromatography using Sephadex G200 .The molecular weight of the enzyme determined by gel filteration was about 82000 dalton with ...
Husain F. Hassan, Jenan A.Saber
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A genome-wide identification and analysis of the DYW-deaminase genes in the pentatricopeptide repeat gene family in cotton (Gossypium spp.). [PDF]
PLoS ONE, 2017 The RNA editing occurring in plant organellar genomes mainly involves the change of cytidine to uridine. This process involves a deamination reaction, with cytidine deaminase as the catalyst.
Bingbing Zhang +11 more
doaj +1 more source
Characteristics and efficacy of cytosine and cytidine deaminase [PDF]
مجلة التربية والعلم, 2007 The study concerned with determination of some properties of cytosine deaminase activity in serum and erythrocytes haemolysate in normal human individuals, by spectral method.
Qusay Chalabi, Zahraa Hammodat
doaj +1 more source
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Cell Reports, 2022 Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd +7 more
doaj +1 more source