A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells [PDF]
Scientific Reports, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová +3 more
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Partial purification of cytidine deaminase from protoscoleces of Echinococcus granulosus [PDF]
Kirkuk Journal of Science, 2015 Cytidine deaminase (EC 3.5.4.5) has been partially purified from protoscoleces of Echinococcus granulosus by gel filteration chromatography using Sephadex G200 .The molecular weight of the enzyme determined by gel filteration was about 82000 dalton with ...
Husain F. Hassan, Jenan A.Saber
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Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells [PDF]
Communications BiologyCytidine deaminase (CDA) converts cytidine and deoxycytidine into uridine and deoxyuridine as part of the pyrimidine salvage pathway. Elevated levels of CDA are found in pancreatic tumors and associated with chemoresistance. Recent evidence suggests that
Audrey Frances +15 more
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Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti
Frontiers in Microbiology, 2021 Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature.
Longxiang Wang +6 more
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A genome-wide identification and analysis of the DYW-deaminase genes in the pentatricopeptide repeat gene family in cotton (Gossypium spp.). [PDF]
PLoS ONE, 2017 The RNA editing occurring in plant organellar genomes mainly involves the change of cytidine to uridine. This process involves a deamination reaction, with cytidine deaminase as the catalyst.
Bingbing Zhang +11 more
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Characteristics and efficacy of cytosine and cytidine deaminase [PDF]
مجلة التربية والعلم, 2007 The study concerned with determination of some properties of cytosine deaminase activity in serum and erythrocytes haemolysate in normal human individuals, by spectral method.
Qusay Chalabi, Zahraa Hammodat
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Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Cell Reports, 2022 Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd +7 more
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Nature Communications, 2023 APOBEC’s are a family of cytidine deaminases that induce mutations in viruses to inhibit their replication and maintain cell integrity. Here, Manjunath et al show that APOBEC3B also inhibits viral replication by stimulating the innate immune sensor ...
Lavanya Manjunath +12 more
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Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions
BMC Biology, 2020 Background Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple
Zhiquan Liu +7 more
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Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
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