Results 11 to 20 of about 38,369 (222)

CDA (Cytidine Deaminase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CDA (Cytidine Deaminase), with data on DNA, on the protein encoded, and where the gene is implicated.
Y Saito, Saito, Y
openaire   +4 more sources

Isoenzymatic forms of human cytidine deaminase [PDF]

Protein Engineering Design and Selection, 2005
Cytidine deaminase (CDA) purified from human placenta revealed the presence of five isoenzymatic forms that differ only in their isoelectric point. Since human cytidine deaminase exists in two variants (CDA 1 and CDA 2) with a non-conservative amino acid substitution at codon 27, in this work we demonstrate that these two variants may combine together ...
VINCENZETTI, Silvia, P. MARIANI, CAMMERTONI, Natalina, POLZONETTI, Valeria, NATALINI, Paolo, B. QUADRINI, VOLPINI, Rosaria, VITA, Alberto   +7 more
openaire   +4 more sources

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Nature Communications, 2017
Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis ...
Elias Bou Samra, Géraldine Buhagiar-Labarchède, Christelle Machon, Jérôme Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, Mounira Amor-Guéret   +9 more
doaj   +2 more sources

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase. [PDF]

PLoS ONE, 2013
Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously.
Rodolphe Suspène, Marie-Ming Aynaud, Jean-Pierre Vartanian, Simon Wain-Hobson   +3 more
doaj   +2 more sources

Human APOBEC1 cytidine deaminase edits HBV DNA [PDF]

Retrovirology, 2009
Retroviruses, hepadnaviruses, and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes, eight have demonstrable enzymatic activity.
Wain-Hobson Simon, Guétard Denise, Henry Michel, Suspène Rodolphe, Gonzalez Minerva, Vartanian Jean-Pierre   +5 more
doaj   +2 more sources

Cytidine deaminase can deaminate fused pyrimidine ribonucleosides. [PDF]

Org Biomol Chem, 2021
The tolerance of Cytidine Deaminase (CDA) to expanded heterocycles is explored via three fluorescent cytidine analogues, where the pyrimidine core is fused to three distinct five-membered heterocycles at the 5/6 positions.
Ludford PT, Li Y, Yang S, Tor Y.
europepmc   +2 more sources

Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs. [PDF]

Cancer Res
Cytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA syntheses and has been shown to protect cancer cells from deoxycytidine-based chemotherapies.
Lumeau A, Bery N, Francès A, Gayral M, Labrousse G, Ribeyre C, Lopez C, Nevot A, El Kaoutari A, Hanoun N, Sarot E, Perrier M, Pont F, Cerapio JP, Fournié JJ, Lopez F, Madrid-Mencia M, Pancaldi V, Pillaire MJ, Bergoglio V, Torrisani J, Dusetti N, Hoffmann JS, Buscail L, Lutzmann M, Cordelier P.   +25 more
europepmc   +2 more sources

APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

Nature Communications, 2023
APOBEC’s are a family of cytidine deaminases that induce mutations in viruses to inhibit their replication and maintain cell integrity. Here, Manjunath et al show that APOBEC3B also inhibits viral replication by stimulating the innate immune sensor ...
Lavanya Manjunath, Sunwoo Oh, Pedro Ortega, Alexis Bouin, Elodie Bournique, Ambrocio Sanchez, Pia Møller Martensen, Ashley A. Auerbach, Jordan T. Becker, Marcus Seldin, Reuben S. Harris, Bert L. Semler, Rémi Buisson   +12 more
doaj   +1 more source

Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions

BMC Biology, 2020
Background Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple
Zhiquan Liu, Siyu Chen, Huanhuan Shan, Yingqi Jia, Mao Chen, Yuning Song, Liangxue Lai, Zhanjun Li   +7 more
doaj   +1 more source

Single-stranded DNA binding proteins influence APOBEC3A substrate preference

Scientific Reports, 2021
The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown, Christopher D. Collins, Secily Thompson, Margo Coxon, Tony M. Mertz, Steven A. Roberts   +5 more
doaj   +1 more source