Results 11 to 20 of about 18,368 (174)
Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.
PLoS Pathogens, 2009 The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of the ...
Iñigo Narvaiza +7 more
doaj +2 more sources
Nature Communications, 2017 Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis ...
Elias Bou Samra +9 more
doaj +2 more sources
Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase. [PDF]
PLoS ONE, 2013 Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously.
Rodolphe Suspène +3 more
doaj +2 more sources
Human APOBEC1 cytidine deaminase edits HBV DNA [PDF]
Retrovirology, 2009 Retroviruses, hepadnaviruses, and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes, eight have demonstrable enzymatic activity.
Wain-Hobson Simon +5 more
doaj +2 more sources
APOBEC3A is a prominent cytidine deaminase in breast cancer.
PLoS Genetics, 2019 APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA).
Luis M Cortez +7 more
doaj +2 more sources
Cytidine deaminase can deaminate fused pyrimidine ribonucleosides. [PDF]
Org Biomol Chem, 2021 The tolerance of Cytidine Deaminase (CDA) to expanded heterocycles is explored via three fluorescent cytidine analogues, where the pyrimidine core is fused to three distinct five-membered heterocycles at the 5/6 positions.
Ludford PT, Li Y, Yang S, Tor Y.
europepmc +2 more sources
Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs. [PDF]
Cancer ResCytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA syntheses and has been shown to protect cancer cells from deoxycytidine-based chemotherapies.
Lumeau A +25 more
europepmc +2 more sources
Activation induced cytidine deaminase: An old friend with new faces. [PDF]
Front Immunol, 2022 Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class switch recombination (CSR). AID also plays critical roles in B cell precursor
Çakan E, Gunaydin G.
europepmc +2 more sources
A Rapid Approach for Identifying Cell Lines Lacking Functional Cytidine Deaminase. [PDF]
Int J Mol SciCDD plays a pivotal role within the pyrimidine salvage pathway. In this study, a novel, rapid method for the identification of cell lines lacking functional cytidine deaminase was developed. This innovative method utilizes immunocytochemical detection of
Ligasová A, Kociánová M, Koberna K.
europepmc +2 more sources
CDA (Cytidine Deaminase) [PDF]
, 2010 Review on CDA (Cytidine Deaminase), with data on DNA, on the protein encoded, and where the gene is ...
Y Saito, Saito, Y
core +1 more source