Results 21 to 30 of about 16,026 (192)
Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions
BMC Biology, 2020 Background Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple
Zhiquan Liu +7 more
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Cytidine Deaminase—A Marker for Pre-Eclampsia? [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1985 Cytidine deaminase (cytidine aminohydrolase, EC 3.5.4.5) was measured in blood collected for routine antenatal monitoring from 590 unselected pregnant women. The enzyme measurements were made without prior knowledge of the clinical condition of the patients.
T J, Baines, A, Clark
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Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
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Isoenzymatic forms of human cytidine deaminase [PDF]
Protein Engineering Design and Selection, 2005 Cytidine deaminase (CDA) purified from human placenta revealed the presence of five isoenzymatic forms that differ only in their isoelectric point. Since human cytidine deaminase exists in two variants (CDA 1 and CDA 2) with a non-conservative amino acid substitution at codon 27, in this work we demonstrate that these two variants may combine together ...
VINCENZETTI, Silvia +7 more
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Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase. [PDF]
PLoS ONE, 2013 Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously.
Rodolphe Suspène +3 more
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AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
Nature Communications, 2018 The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity.
Mei-Chen Liu +5 more
doaj +1 more source
BMC Cancer, 2020 Background Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is ...
Claire M. Connell +8 more
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Restriction of Foamy Viruses by APOBEC Cytidine Deaminases [PDF]
Journal of Virology, 2006 ABSTRACT Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV.
Delebecque, Frédéric +9 more
openaire +4 more sources
APOBEC3G & HTLV-1: Inhibition without deamination
Retrovirology, 2005 APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines.
Strebel Klaus
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Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.
PLoS Pathogens, 2021 The APOBEC3 (A3) genes encode cytidine deaminase proteins with potent antiviral and anti-retroelement activity. This locus is characterized by duplication, recombination, and deletion events that gave rise to the seven A3s found in primates.
Mollie M McDonnell +5 more
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