Results 21 to 30 of about 18,368 (174)
AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
Nature Communications, 2018 The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity.
Mei-Chen Liu +5 more
doaj +1 more source
BMC Cancer, 2020 Background Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is ...
Claire M. Connell +8 more
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APOBEC3G & HTLV-1: Inhibition without deamination
Retrovirology, 2005 APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines.
Strebel Klaus
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Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.
PLoS Pathogens, 2021 The APOBEC3 (A3) genes encode cytidine deaminase proteins with potent antiviral and anti-retroelement activity. This locus is characterized by duplication, recombination, and deletion events that gave rise to the seven A3s found in primates.
Mollie M McDonnell +5 more
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In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
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Multiple gene substitution by Target-AID base-editing technology in tomato
Scientific Reports, 2020 The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker +5 more
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Clinical study of cytidine deaminase in serum of cancer thalassemia and diabetes patients [PDF]
مجلة التربية والعلم, 2010 This research included a clinical study of cytidine deaminase activity in serum, which included of seven types of cancer patients involve larynx, lung, renal, bladder, sarcoma, prostate and seminomia and Thalassemia patients as well as, diabetes patients.
Zahra Hammoudat
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Crystal structure of Arabidopsis thaliana cytidine deaminase
, 2020 Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants.
Wang, Jia, Wang, Xiao, Guo, Qi, Liu, Lin
core +1 more source
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Nature Communications, 2018 CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri +9 more
doaj +1 more source
mSphere, 2019 Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes +6 more
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