Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.
PLoS Pathogens, 2021 The APOBEC3 (A3) genes encode cytidine deaminase proteins with potent antiviral and anti-retroelement activity. This locus is characterized by duplication, recombination, and deletion events that gave rise to the seven A3s found in primates.
Mollie M McDonnell +5 more
doaj +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
doaj +1 more source
Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation [PDF]
, 2006 APOBEC3G and APOBEC3F restrict human immunodeficiency virus type 1 (HIV-1) replication in vitro through the induction of G!92A hypermutation; however, the relevance of this host antiviral strategy to clinical HIV-1 is currently not known.
Pace, C. +6 more
core +2 more sources
Multiple gene substitution by Target-AID base-editing technology in tomato
Scientific Reports, 2020 The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker +5 more
doaj +1 more source
Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]
, 2017 Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin +10 more
core +3 more sources
Clinical study of cytidine deaminase in serum of cancer thalassemia and diabetes patients [PDF]
مجلة التربية والعلم, 2010 This research included a clinical study of cytidine deaminase activity in serum, which included of seven types of cancer patients involve larynx, lung, renal, bladder, sarcoma, prostate and seminomia and Thalassemia patients as well as, diabetes patients.
Zahra Hammoudat
doaj +1 more source
The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
, 2014 Peer reviewedPublisher ...
Chen +22 more
core +2 more sources
CDA (Cytidine Deaminase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CDA (Cytidine Deaminase), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Nature Communications, 2018 CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri +9 more
doaj +1 more source