Results 51 to 60 of about 38,369 (222)

Vaccinia virus replication is not affected by APOBEC3 family members [PDF]

, 2006
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Kremer Melanie, Schnierle Barbara S, Yasemin Suezer, Suezer, Yasemin, Martinez-Fernandez Yolanda, Schnierle, Barbara, Münk Carsten, Sutter, Gerd, Yolanda Martinez-Fernandez, Melanie Kremer, Barbara S Schnierle, Münk, Carsten, Suezer Yasemin, Gerd Sutter, Martinez-Fernandez, Yolanda, Carsten Münk, Kremer, Melanie   +17 more
core   +1 more source

Engineering a Cytidine Aminotransferase for Biocatalytic Production of the Antiviral Molnupiravir [PDF]

, 2021
The COVID-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue currently in phase 3 clinical trials as ...
Carl, Young, Ian, Rowles, Rebecca, Crawshaw, Sarah, Lovelock, Anthony, Green, Ashleigh, Burke, Bruna Zuculoto da, Costa, Nicholas, Turner, William, Birmingham, James, Finnigan, Ying, Zhuo, Simon J., Charnock, Thomas, Thorpe   +12 more
core   +1 more source

Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase

, 2002
A composition, device, kit and method for countering or diagnosing cytidine deaminase or deoxycytidine deaminase over-expression or a disorder associated with it, or an increase in number or toxicity of pro-inflammatory cells that over-express cytidine ...
Nyce, Jonathan W.
core   +2 more sources

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

A Quantum Chemical Study of the Catalysis for Cytidine Deaminase:  Contribution of the Extra Water Molecule

, 2016
Cytidine deaminase is known as an important enzyme responsible for the hydrolytic deamination of cytidine, which is applied as a key step to the conversion of the precursor of the cancer drug to an active form in the living body.
Masashi Ishikura (2639875), Misako Aida (685555), Toshiaki Matsubara (1745320)   +2 more
core   +1 more source

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G. [PDF]

PLoS ONE, 2009
Hepatitis B virus (HBV) DNA is vulnerable to editing by human cytidine deaminases of the APOBEC3 (A3A-H) family albeit to much lower levels than HIV cDNA.
Michel Henry, Denise Guétard, Rodolphe Suspène, Christophe Rusniok, Simon Wain-Hobson, Jean-Pierre Vartanian   +5 more
doaj   +1 more source

Cytidine Deaminase Activity Drives Cytotoxicity of Modified Cytidines [PDF]

Cancer Discovery, 2015
Abstract Cytidine deaminase (CDA) overexpression confers susceptibility to epigenetically modified cytidines.
openaire   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.

PLoS ONE, 2015
Cytidine is an industrially useful precursor for the production of antiviral compounds and a variety of industrial compounds. Interest in the microbial production of cytidine has grown recently and high-throughput screening of cytidine over-producers is ...
Huina Dong, Yongfei Liu, Xin Zu, Ning Li, Feiran Li, Dawei Zhang   +5 more
doaj   +1 more source