Results 71 to 80 of about 30,296 (276)

Control of Human Anelloviruses by Cytosine to Uracil Genome Editing

mSphere, 2022
Anelloviruses are the most common viruses infecting humans. Every human carries a nonpathogenic personal anellovirus virome (anellome), yet it is unknown which mechanisms contribute to its stability.
Anne L. Timmerman, Joanna Kaczorowska, Martin Deijs, Margreet Bakker, Lia van der Hoek   +4 more
doaj   +1 more source

Dynamic Switchable and Transient DNA Condensates Driven by Aptamer‐Ligand or Ion‐Nucleobase Bridged Complexes

Small, EarlyView.
Switchable or transient formation and dissociation of the phase‐separated DNA microdroplets generated by metal ions or aptamer‐ligand complexes crosslinking Y‐shaped DNA frameworks and dynamically separated by counter ligands eliminating the bridging metal ions or biocatalysts degrading the aptamer‐ligand complexes, are introduced.
Yichen Han, Yang Sung Sohn, Rachel Nechushtai, Fan Xia, Fujian Huang, Yunlong Qin, Itamar Willner   +6 more
wiley   +1 more source

An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.

PLoS ONE, 2015
Cytidine is an industrially useful precursor for the production of antiviral compounds and a variety of industrial compounds. Interest in the microbial production of cytidine has grown recently and high-throughput screening of cytidine over-producers is ...
Huina Dong, Yongfei Liu, Xin Zu, Ning Li, Feiran Li, Dawei Zhang   +5 more
doaj   +1 more source

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. [PDF]

, 2012
Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations ...
Begum, Nasim A, Burroughs, A Maxwell, Daub, Carsten O, Doi, Tomomitsu, Hayashizaki, Yoshihide, Honjo, Tasuku, Kato, Lucia, Kawaguchi, Takahisa, Kawai, Jun, Matsuda, Fumihiko   +9 more
core   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Biological function of activation-induced cytidine deaminase (AID)

Biomedical Journal, 2014
Activation-induced Cytidine Deaminase (AID) is an essential regulator of B cell diversification, but its full range of action has until recently been an enigma. Based on homology, it was originally proposed to be an RNA-editing enzyme, but so far, no RNA
Ritu Kumar, Lauren J DiMenna, Jayanta Chaudhuri, Todd Evans   +3 more
doaj   +1 more source

AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer [PDF]

, 2016
Background Building up of pathway-/disease-relevant signatures provides a persuasive tool for understanding the functional relevance of gene alterations and gene network associations in multifactorial human diseases.
Birner, Peter, Braicu, Ioana, Castillo-Tong,Dan Cacsire, Hager, Gudrun, Heinze, Georg, Jaritz, Markus, Jensen-Jarolim, Erika, Lambrechts, Sandrina, Mahner, Sven, Mechtcheriakova, Diana, Meshcheryakova, Anastasia, Pils, Dietmar, Sehouli, Jalid, Svoboda, Martin, Thalhammer, Theresia, Vergote, Ignace, Zeillinger, Robert, Zimmermann, Philip   +17 more
core   +2 more sources

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

The FEBS Journal, EarlyView.
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley   +1 more source

Activation-induced cytidine deaminase: in sickness and in health. [PDF]

J Cancer Res Clin Oncol, 2020
Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and changing affinity. This is possible through its DNA deaminase function, leading to mutations in DNA.
Rios LAS, Cloete B, Mowla S.
europepmc   +3 more sources