Results 81 to 90 of about 18,368 (174)
Vaccinia virus replication is not affected by APOBEC3 family members
, 2006 Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +17 more
core +1 more source
Studies on thermal stability of human cytidine deaminase
, 2007 The thermal stability of human cytidine deaminase (CDA), an enzyme involved in pyrimidine metabolism was investigated. With this in view, the residues R68 and Y60, supposed to be involved in the intersubunit interactions and in the catalytic site of ...
VITA, Alberto +6 more
core +1 more source
Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
Cell ReportsSummary: Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human APOBEC3A (hA3A) improves CBE properties.
Chun-Yan Ren +6 more
doaj +1 more source
Cytidine deaminase as a molecular target in cancer: an insight
, 2017 Cancer is one of the leading causes of death globally. Although more than 400 varieties of cancer have been reported, based on cell lines, still the actual reason of all types of cancer is not very clear.
Bandyopadhyay, Debasish +1 more
core +1 more source
Maize haplotype with a
BMC Genetics, 2006 Background Genetic maps are based on recombination of orthologous gene sequences between different strains of the same species. Therefore, it was unexpected to find extensive non-collinearity of genes between different inbred strains of maize ...
Messing Joachim, Xu Jian-Hong
doaj +1 more source
Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
Molecular & Cellular Oncology, 2018 The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
doaj +1 more source
, 2004 The capacity to class switch the IgH chain is critical to the effectiveness of humoral immune responses. We show that in vitro-stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes (IgG1, G2a, G3 ...
D. Frasca +7 more
core +1 more source
Precise Creation of Elite Multilocular Germplasm Using a CBE NG System in Brassica napus
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4716-4718, July 2026.
Huailin Li +8 more
wiley +1 more source
, 2016 To decrease the costs of producing the anti-HIV drug, lamivudine, an enzymatic conversion process was developed instead of the traditional chemical method. Thermostable cytidine deaminase was over-produced by cloning the cdd gene into E.
정낙신
core +1 more source
In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells
, 1997 Cytidine deaminase can cause the deamination of cytotoxic analogues of cytidine or rescue cells from the cytotoxicity of uracil analogues. Therefore, cytidine deaminase influences the cytotoxicity exerted by these compounds.
van Kuilenburg, A. B. +4 more
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