Results 81 to 90 of about 38,369 (222)
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source
Haematologica, 2008 Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi +9 more
doaj +1 more source
Genome Biology, 2020 We describe here a CRISPR simultaneous and wide-editing induced by a single system (SWISS), in which RNA aptamers engineered in crRNA scaffold recruit their cognate binding proteins fused with cytidine deaminase and adenosine deaminase to Cas9 nickase ...
Chao Li +8 more
doaj +1 more source
Journal of Integrative Plant Biology, EarlyView.This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley +1 more source
AI foundation models in plant biology
New Phytologist, EarlyView.Foundation models decode genomes, engineer proteins, phenotype crops, and drive AI agents across plant biology. This figure was created in BioRender (BioRender.com/xcmmkel). Summary Rapid technological progress has enabled plant biologists to accumulate unprecedented volumes of multi‐scale, multi‐modal data, yet this abundance of data has intensified ...
Haopeng Yu
wiley +1 more source
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.
PLoS Pathogens, 2009 The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates.
Hendrik Huthoff +4 more
doaj +1 more source
BMC Biology, 2018 Background Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break.
Matthew A. Coelho +8 more
doaj +1 more source
International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari +10 more
wiley +1 more source
A diagram showing the distinct targets of adenosine and cytidine deaminase in the HIV-1 life cycle.
, 2014 IFN-γ induces both adenosine deaminase (ADAR1L) and cytidine deaminase (APOBEC3G). Adenosine deaminase may inhibit the step after viral transcription whereas cytidine deaminase acts on reverse transcription immediately after virus entry.
Rodney Dawson (101812) +10 more
core +1 more source
The Myeloma Risk Variant of TNFRSF13B Shows Reduced NF‐κB Signalling Activity in HEK293 Cells
European Journal of Haematology, Volume 117, Issue 5, Page 1391-1396, November 2026.ABSTRACT A single nucleotide variant rs34562254 in TNFRSF13B, which encodes TACI (transmembrane activator and CAML interactor), is associated with an increased risk of myeloma and MGUS. This variant encodes a proline to leucine substitution at residue 251 in the long isoform (P251L) and residue 205 in the short isoform (P205L) of TACI.
Richard Muyan Chen +5 more
wiley +1 more source