Results 91 to 100 of about 38,369 (222)

AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines

Neoplasia: An International Journal for Oncology Research, 2020
The BCL6 proto-oncogene encodes a transcriptional repressor, which is required for germinal centers (GCs) formation and lymphomagenesis. Previous studies have been reported that the constitutive expression of BCL6 leads to diffuse large B cell lymphoma ...
Junna Jiao, Zhuangwei Lv, Ping Zhang, Yang Wang, Meng Yuan, Xiaozhuo Yu, Woodvine Otieno Odhiambo, Mingzhe Zheng, Hua Zhang, Yunfeng Ma, Yanhong Ji   +10 more
doaj   +1 more source

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3397-3406, October 2026.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source

Genome Using Cytidine Deaminase Combined with the CRISPR/Cas9 System

, 2020
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimThe oleaginous yeast Yarrowia lipolytica has a tendency to use the non-homologous end joining repair (NHEJ) over the homology directed recombination as double-strand breaks (DSB) repair system, making ...
Byung‐Gee Kim, Beom Gi Park, Park, Beom Gi, Kim, Byung-Gee, Ji‐Sook Hahn, Hahn, Ji-Sook, Bae, Sang-Jeong, Sang‐Jeong Bae   +7 more
core   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing

Cell Reports
Summary: Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human APOBEC3A (hA3A) improves CBE properties.
Chun-Yan Ren, Yan-Shan Liu, Yu-Shan He, Lin-Pei Zhang, Jun-Hua Rao, Yijian Rao, Jian-Huan Chen   +6 more
doaj   +1 more source

Somatic Mitochondrial–Nuclear DNA Transfer in Lymphoproliferative Disorders

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Somatic mitochondrial–nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods EuroClonality‐NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for ...
James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V. Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W. Langerak, David Gonzalez   +9 more
wiley   +1 more source

Maize haplotype with a helitron-amplified cytidine deaminase gene copy

BMC Genetics, 2006
Background Genetic maps are based on recombination of orthologous gene sequences between different strains of the same species. Therefore, it was unexpected to find extensive non-collinearity of genes between different inbred strains of maize ...
Messing Joachim, Xu Jian-Hong
doaj   +1 more source

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response

MedComm, Volume 7, Issue 10, October 2026.
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu, Jie Yu, Ying Chen, Shengfang Ge, Lin Ye, Yefei Wang, Yixiong Zhou, Renbing Jia   +7 more
wiley   +1 more source

Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association

Molecular & Cellular Oncology, 2018
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
doaj   +1 more source

A rapid and efficient in planta assay for assessment of RNA editing factor performance

The Plant Journal, Volume 128, Issue 1, October 2026.
Significance Statement Nuclear‐encoded pentatricopeptide repeat (PPR) proteins perform site‐specific cytidine‐to‐uridine RNA editing in plant organellar transcripts. Their RNA‐binding specificity can be engineered, enabling targeted de novo RNA editing.
Elena Lesch, Dennis Brandt, Markus Schwarzländer, Till Ischebeck   +3 more
wiley   +1 more source