Results 91 to 100 of about 30,296 (276)
Haematologica, 2008 Background Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10–15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases ...
Éva Gagyi +9 more
doaj +1 more source
Genome Biology, 2020 We describe here a CRISPR simultaneous and wide-editing induced by a single system (SWISS), in which RNA aptamers engineered in crRNA scaffold recruit their cognate binding proteins fused with cytidine deaminase and adenosine deaminase to Cas9 nickase ...
Chao Li +8 more
doaj +1 more source
MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [PDF]
, 2016 MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with ...
Alivernini, Stefano +13 more
core +2 more sources
Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns
Journal of Integrative Plant Biology, EarlyView.Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng +5 more
wiley +1 more source
BMC Biology, 2018 Background Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break.
Matthew A. Coelho +8 more
doaj +1 more source
Journal of Integrative Plant Biology, EarlyView.Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen +8 more
wiley +1 more source
The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine [PDF]
, 2016 Decitabine (5-aza-2acute;-deoxycytidine, aza-dCyd) is an anticancer drug used clinically for the treatment of myelodysplastic syndromes and acute myeloid leukemia that can act as a DNA-demethylating or genotoxic agent in a dose-dependent manner.
Horváth, András +4 more
core +1 more source
RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.
PLoS Pathogens, 2009 The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates.
Hendrik Huthoff +4 more
doaj +1 more source
Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]
, 2013 Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
core +1 more source
eJHaem, Volume 7, Issue 3, June 2026.ABSTRACT Translocations involving CCND1 are well described in multiple myeloma (MM), most frequently t(11;14), but rearrangements involving the immunoglobulin kappa (IGK) locus are rare. We present a case of a 71‐year‐old female with MM harboring t(2;11)(p11.2;q13), resulting in IGK::CCND1, with cyclin D1 and BCL‐2 overexpression.
Ariel Siegel +7 more
wiley +1 more source