Results 91 to 100 of about 18,368 (174)

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Nature Communications, 2017
Third-generation base editors consist of a catalytically disabled Cas9 fused to a cytidine deaminase and a base excision repair inhibitor, enabling efficient, precise editing of individual base pairs in DNA.
Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge, David R. Liu   +6 more
doaj   +1 more source

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity

Tumour Virus Research
Simian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl, Anni I. Soikkeli, Salomé Prost, David G. Schatz, Martina Slavková, Jiří Hejnar, Jukka Alinikula   +6 more
doaj   +1 more source

Ab Initio ONIOM−Molecular Dynamics (MD) Study on the Deamination Reaction by Cytidine Deaminase

, 2016
We applied the ONIOM−molecular dynamics (MD) method to the hydrolytic deamination of cytidine by cytidine deaminase, which is an essential step of the activation process of the anticancer drug inside the human body.
Michel Dupuis (1294080), Misako Aida (685555), Toshiaki Matsubara (1745320)   +2 more
core   +1 more source

Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

, 2020
The antibodies of jawless vertebrates consist of leucine-rich repeat arrays encoded by somatically assembled VLRB genes. It is unknown how the incomplete germline VLRB loci are converted into functional antibody genes during B lymphocyte development in ...
Evanno, G., Boehm, T., Vassaux, Danièle, Vassaux, D., Boehm, T. ; https://orcid.org/, Schorpp, Michael, Morimoto, R., O’Meara, C., Iwanami, N., Evanno, Guillaume, Souissi, A., Giorgetti, Orlando Bruno, Souissi, Ahmed, Giorgetti, Orlando, Holland, Stephen, Trancoso, Inês, Giorgetti, O., O’meara, Connor, Holland, S., Schorpp, M., Iwanami, Norimasa, Boehm, Thomas, O’Meara, Connor P., Holland, Stephen J., Morimoto, Ryo, Trancoso, I.   +25 more
core   +1 more source

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

PLoS ONE, 2008
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR).
Koji Hase, Daisuke Takahashi, Masashi Ebisawa, Sayaka Kawano, Kikuji Itoh, Hiroshi Ohno   +5 more
doaj   +1 more source

Structure of Human Cytidine Deaminase Bound to a Potent Inhibitor

, 2016
Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report
J. Christopher Fromme (2693497), Gregory L. Verdine (11056), Sang J. Chung (2693494)   +2 more
core   +1 more source

Yin and yang of cytidine deaminase roles in clinical response to azacitidine in the elderly: a pharmacogenetics tale.

, 2015
International audienceAzacitidine is a mainstay for treating hematological disorders. Azacitidine is metabolized by cytidine deaminase, coded by a highly polymorphic gene.
J, Ciccolini, J, Colle, L, Ouafik, G, Venton, C, Serdjebi, B, Lacarelle, C, Mercier, R., Costello, F, Fina, R, Fanciullino   +9 more
core   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

, 2010
The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID's promiscuity and its predilection for immunoglobulin genes are unknown.
Stefan Kuchen, Wolfgang Resch, Arito Yamane, Yamane, Arito, Nan Kuo, Michel C Nussenzweig, Sun, Hong-wei, Kevin McBride, Kuchen, Stefan, Kuo, Nan, Nussenzweig, Michel C, Rafael Casellas, Casellas, Rafael, Li, Zhiyu, Hong-wei Sun, Davide F Robbiani, Robbiani, Davide F, Zhiyu Li, McBride, Kevin, Resch, Wolfgang   +19 more
core   +1 more source

Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID).

, 2013
Virus infection is restricted by intracellular immune responses in host cells, and this is typically modulated by stimulation of cytokines. The cytokines and host factors that determine the host cell restriction against hepatitis B virus (HBV) infection ...
Murata, Kazumoto, Tong, Shuping, Kitamura, Kouichi, Uchida, Nanako, 84207, Marusawa, Hiroyuki, 84206, Li, Jisu, 84209, 84208, 20359813, 84203, Iwamoto, Masashi, 喜多村, 晃一, 84202, 84205, 84204, Watashi, Koichi, Ohashi, Hirofumi, 70378892, Liang, Guoxin, Kiyohara, Tomoko, Daito, Takuji, Wakita, Takaji, 84218, Aizaki, Hideki, 84217, 84214, Muramatsu, Masamichi, 84213, 村松, 正道, 84216, 84215, 84210, Suzuki, Ryosuke, 84212, 84211, Tanaka, Yasuhito   +37 more
core   +1 more source