Results 101 to 110 of about 38,369 (222)

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID). [PDF]

, 2013
Virus infection is restricted by intracellular immune responses in host cells, and this is typically modulated by stimulation of cytokines. The cytokines and host factors that determine the host cell restriction against hepatitis B virus (HBV) infection ...
Murata, Kazumoto, Tong, Shuping, Kitamura, Kouichi, Uchida, Nanako, 84207, Marusawa, Hiroyuki, 84206, Li, Jisu, 84209, 84208, 20359813, 84203, Iwamoto, Masashi, 喜多村, 晃一, 84202, 84205, 84204, Watashi, Koichi, Ohashi, Hirofumi, 70378892, Liang, Guoxin, Kiyohara, Tomoko, Daito, Takuji, Wakita, Takaji, 84218, Aizaki, Hideki, 84217, 84214, Muramatsu, Masamichi, 84213, 村松, 正道, 84216, 84215, 84210, Suzuki, Ryosuke, 84212, 84211, Tanaka, Yasuhito   +37 more
core   +1 more source

Functional analysis of the two cytidine deaminase domains in APOBEC3G [PDF]

, 2011
Human APOBEC3G (hA3G), a cytidine deaminase with two cytidine deaminase domains (CDs), has been identified as an anti-HIV-1 host factor. Although the two CDs of hA3G have been extensively characterized, there is still debate on the role of the CDs in the
Jinming Zhou, Xuefu You, Shan Cen, Zhou, Jinming, Li, Zelin, Jing Ma, Fei Guo, Lixun Zhao, Yi Zeng, Zelin Li, Li, Xiaoyu, Liyan Yu, Xiao Yin, Zeng, Yi, Quan Zhang, Zhai, Congjie, Yin, Xiao, Xiaoyu Li, Congjie Zhai, Guo, Fei, Cen, Shan, Ma, Jing, Yu, Liyan, Zhang, Quan, You, Xuefu, Zhao, Lixun   +25 more
core   +1 more source

Cytidine-Derived Hydrogels with Tunable Antibacterial Activities

, 2019
We herein report the preparation of hydrogels by the Ag+ ion induced assembly of cytidine and boronic acids. These hydrogels, presumably formed by an i-motif like arrangement of cytidine and its boronate ester analogues, possess excellent thixotropic and
Jyotirmayee Dash (1616845), Ritapa Chaudhuri (6752060), Tanima Bhattacharyya, Subhranshu Mandal (6945374), Subhranshu Mandal, Krishna Sundar Das, Ritapa Chaudhuri, Raju Mondal, Jyotirmayee Dash, Krishna Sundar Das (6171356), Tanima Bhattacharyya (4475041), Raju Mondal (20176)   +11 more
core   +1 more source

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Nature Communications, 2017
Third-generation base editors consist of a catalytically disabled Cas9 fused to a cytidine deaminase and a base excision repair inhibitor, enabling efficient, precise editing of individual base pairs in DNA.
Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge, David R. Liu   +6 more
doaj   +1 more source

Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase

, 2004
The capacity to class switch the IgH chain is critical to the effectiveness of humoral immune responses. We show that in vitro-stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes (IgG1, G2a, G3 ...
D. Frasca, Frasca, Daniela, R. L. Riley, E. Van der Put, B. B. Blomberg, Blomberg, Bonnie B, Van der Put, Elaine, Riley, Richard L   +7 more
core   +1 more source

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

PLoS ONE, 2008
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR).
Koji Hase, Daisuke Takahashi, Masashi Ebisawa, Sayaka Kawano, Kikuji Itoh, Hiroshi Ohno   +5 more
doaj   +1 more source

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity

Tumour Virus Research
Simian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl, Anni I. Soikkeli, Salomé Prost, David G. Schatz, Martina Slavková, Jiří Hejnar, Jukka Alinikula   +6 more
doaj   +1 more source

In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells

, 1997
Cytidine deaminase can cause the deamination of cytotoxic analogues of cytidine or rescue cells from the cytotoxicity of uracil analogues. Therefore, cytidine deaminase influences the cytotoxicity exerted by these compounds.
van Kuilenburg, A. B., Bodlaender, J. M., Voûte, P. A., van Gennip, A. H., Slingerland, R. J.   +4 more
core  

Lamivudine production via enantioselective deamination by thermostable Bacillus caldolyticus cytidine deaminase

, 2016
To decrease the costs of producing the anti-HIV drug, lamivudine, an enzymatic conversion process was developed instead of the traditional chemical method. Thermostable cytidine deaminase was over-produced by cloning the cdd gene into E.
정낙신
core   +1 more source