Results 111 to 120 of about 38,369 (222)

Ab Initio ONIOM−Molecular Dynamics (MD) Study on the Deamination Reaction by Cytidine Deaminase

, 2016
We applied the ONIOM−molecular dynamics (MD) method to the hydrolytic deamination of cytidine by cytidine deaminase, which is an essential step of the activation process of the anticancer drug inside the human body.
Michel Dupuis (1294080), Misako Aida (685555), Toshiaki Matsubara (1745320)   +2 more
core   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source

Structure of Human Cytidine Deaminase Bound to a Potent Inhibitor

, 2016
Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report
J. Christopher Fromme (2693497), Gregory L. Verdine (11056), Sang J. Chung (2693494)   +2 more
core   +1 more source

Yin and yang of cytidine deaminase roles in clinical response to azacitidine in the elderly: a pharmacogenetics tale.

, 2015
International audienceAzacitidine is a mainstay for treating hematological disorders. Azacitidine is metabolized by cytidine deaminase, coded by a highly polymorphic gene.
J, Ciccolini, J, Colle, L, Ouafik, G, Venton, C, Serdjebi, B, Lacarelle, C, Mercier, R., Costello, F, Fina, R, Fanciullino   +9 more
core   +1 more source

Antigen receptors and somatic hypermutation in B-cell chronic lymphocytic leukemia with Richter's transformation

Haematologica, 2006
BACKGROUND AND OBJECTIVES: Activation-induced cytidine deaminase is essential for somatic hypermutation and class switch recombination of the immunoglobulin genes in B cells.
LA Smit, F van Maldegem, AW Langerak, CE van der Schoot, MJ de Wit, S Bea, E Campo, RJ Bende, CJ van Noesel   +8 more
doaj  

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Bioresources and Bioprocessing
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline.
Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li   +3 more
doaj   +1 more source

The influence of APOBEC3G and deoxythymidylate kinase genetic diversity on HIV-1 hypermutation and response to treatment [PDF]

, 2006
This thesis addresses two important topics in HIV-1 medicine; (i) the clinical relevance of pre-treatment G-A hypermutation and the contribution of host and viral genetics to its development and; (ii) the influence of genetic variation in host enzymes ...
Pace, Craig Stuart
core  

Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

Nature Communications
APOBEC3G, part of the AID/APOBEC cytidine deaminase family, is crucial for antiviral immunity. It has two zinc-coordinated cytidine-deaminase domains.
Hanjing Yang, Josue Pacheco, Kyumin Kim, Ayub Bokani, Fumiaki Ito, Diako Ebrahimi, Xiaojiang S. Chen   +6 more
doaj   +1 more source

Cytidine Deaminase [PDF]

, 2020
openaire   +1 more source

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

, 2010
The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID's promiscuity and its predilection for immunoglobulin genes are unknown.
Stefan Kuchen, Wolfgang Resch, Arito Yamane, Yamane, Arito, Nan Kuo, Michel C Nussenzweig, Sun, Hong-wei, Kevin McBride, Kuchen, Stefan, Kuo, Nan, Nussenzweig, Michel C, Rafael Casellas, Casellas, Rafael, Li, Zhiyu, Hong-wei Sun, Davide F Robbiani, Robbiani, Davide F, Zhiyu Li, McBride, Kevin, Resch, Wolfgang   +19 more
core   +1 more source