Results 61 to 70 of about 38,369 (222)
Animal Research and One Health, EarlyView.The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang +4 more
wiley +1 more source
Control of Human Anelloviruses by Cytosine to Uracil Genome Editing
mSphere, 2022 Anelloviruses are the most common viruses infecting humans. Every human carries a nonpathogenic personal anellovirus virome (anellome), yet it is unknown which mechanisms contribute to its stability.
Anne L. Timmerman +4 more
doaj +1 more source
A Novel Cytidine Deaminase Affects Antibody Diversity [PDF]
Cell, 2000 It has not been determined whether AID normally acts as a DNA or RNA deaminase. In vitro, deamination of monomeric deoxycytidine was efficient (Muramatsu et al. 1999xMuramatsu, M, Sankaranand, V, Anant, S, Sugai, M, Kinoshita, K, Davidson, N, and Honjo, T. J. Biol. Chem.
Longacre, Angelika, Storb, Ursula
openaire +2 more sources
Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
, 2007 APOBEC3 cytidine deaminases hypermutate hepatitis B virus (HBV) and inhibit its replication in vitro. Whether this inhibition is due to the generation of hypermutations or to an alternative mechanism is controversial.
Greeve, Jobst, Bonvin, Marianne
core +1 more source
Biological function of activation-induced cytidine deaminase (AID)
Biomedical Journal, 2014 Activation-induced Cytidine Deaminase (AID) is an essential regulator of B cell diversification, but its full range of action has until recently been an enigma. Based on homology, it was originally proposed to be an RNA-editing enzyme, but so far, no RNA
Ritu Kumar +3 more
doaj +1 more source
Cancer Nexus, EarlyView.Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang +7 more
wiley +1 more source
Cytidine deaminase variants for base editing
, 2021 Nucleotide sequences coding for variants of the cytidine deaminase protein characterised by specific point mutations, and their use in the preparation of fusion proteins with Cas-9 for use in DNA editing techniques are ...
Francesco Severi +2 more
core
Cytidine deaminase as a molecular target in cancer: an insight [PDF]
, 2017 Cancer is one of the leading causes of death globally. Although more than 400 varieties of cancer have been reported, based on cell lines, still the actual reason of all types of cancer is not very clear.
Bandyopadhyay, Debasish +1 more
core +1 more source
Deciphering transcriptome complexity via long‐read sequencing
iMeta, EarlyView.Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu +21 more
wiley +1 more source