Results 31 to 40 of about 16,026 (192)
Resistance of Cyclocytidine to Cytidine Deaminase
Chemical and Pharmaceutical Bulletin, 1973 Deamination of cytidine derivatives especially of cyclocytidine by mouse kidney cytidine deaminase was examined. Cyclocytidine was not deaminated at either pH6.5 or pH7.3 by the enzyme. Furthermore, cyclocytidine did not inhibit the deamination of aracytidine and ([I]/[S])0.5 value for cyclocytidine was over 100.
HOSHI, AKIO +3 more
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In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
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Multiple gene substitution by Target-AID base-editing technology in tomato
Scientific Reports, 2020 The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker +5 more
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Clinical study of cytidine deaminase in serum of cancer thalassemia and diabetes patients [PDF]
مجلة التربية والعلم, 2010 This research included a clinical study of cytidine deaminase activity in serum, which included of seven types of cancer patients involve larynx, lung, renal, bladder, sarcoma, prostate and seminomia and Thalassemia patients as well as, diabetes patients.
Zahra Hammoudat
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Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Nature Communications, 2018 CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri +9 more
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CDA (Cytidine Deaminase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CDA (Cytidine Deaminase), with data on DNA, on the protein encoded, and where the gene is implicated.
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Structural features of antiviral DNA cytidine deaminases [PDF]
bchm, 2013 Abstract The APOBEC3 (A3) family of cytidine deaminases plays a vital role for innate defense against retroviruses. Lentiviruses such as HIV-1 evolved the Vif protein that triggers A3 protein degradation. There are seven A3 proteins, A3A-A3H, found in humans.
Vasudevan, Ananda Ayyappan Jaguva +5 more
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Human placenta cytidine deaminase: a zinc metalloprotein [PDF]
IUBMB Life, 1997 AbstractCytidine deaminase, a tetrameric enzyme purified from human placenta, was shown to contain a single atom of tightly bound zinc per subunit by Inductively Coupled Plasma Optical Emission Spectrometry analysis. The metal appears to be involved in catalysis, as suggested by the inhibition exerted by 1,10‐phenanthroline and dipicolinic acid.
VINCENZETTI, Silvia +5 more
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APOBEC3s: DNA‐editing human cytidine deaminases [PDF]
Protein Science, 2019 AbstractNucleic acid editing enzymes are essential components of the human immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins. Among these enzymes are cytidine deaminases of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide‐like (APOBEC) super family, each with unique target sequence specificity and ...
Tania V. Silvas, Celia A. Schiffer
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A putative antiviral role of plant cytidine deaminases [PDF]
F1000Research, 2014 Summary A mechanism of innate antiviral immunity operating against viruses infecting mammalian cells has been described during the last decade. Host cytidine deaminases (e.g., APOBEC3 proteins) edit viral genomes giving raise to hypermutated nonfunctional viruses; consequently, viral fitness is reduced through lethal ...
Susana Martín +3 more
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