Results 11 to 20 of about 46,251 (223)

Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. [PDF]

PLoS Pathogens, 2005
The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the
Viviana Simon, Veronique Zennou, Deya Murray, Yaoxing Huang, David D Ho, Paul D Bieniasz   +5 more
doaj   +2 more sources

Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

Cell Death Discovery, 2022
Highly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme of the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections and cancer.
Twana Alkasalias, Juan Zhang, Harsha Madapura, Basile Dalaroun, Oscar Bedoya Reina, Rolf Lewensohn, Kristina Viktorsson, Abbas Salihi, Suhas Darekar, Sonia Laín   +9 more
doaj   +1 more source

Association of Inosine and Cytidine

Biophysical Journal, 1971
A rigorous theory for the analysis of an associating system involving two different monomer units, which may also undergo self-association, has been developed. In the present paper the application of the theory to actual data is demonstrated for the first time.
Magar, M.E., Steiner, R.F., Kolinski, R.
openaire   +2 more sources

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Exploring ABOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer

iScience, 2022
Summary: APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to uracil. Many studies have established a link between APOBEC3 expression and cancer development and progression, especially APOBEC3A (A3A) and APOBEC3B (A3B ...
Christina Papini, Zechen Wang, Shalley N. Kudalkar, Travis Parke Schrank, Su Tang, Tomoaki Sasaki, Cory Wu, Brandon Tejada, Samantha J. Ziegler, Yong Xiong, Natalia Issaeva, Wendell G. Yarbrough, Karen S. Anderson   +12 more
doaj   +1 more source

The photophysics of protonated cytidine and hemiprotonated cytidine base pair: A computational study

Photochemistry and Photobiology, 2023
AbstractWe here study the effect that a lowering of the pH has on the excited state processes of cytidine and a cytidine/cytidine pair in solution, by integrating time‐dependent density functional theory and CASSCF/CASPT2 calculations, and including solvent by a mixed discrete/continuum model.
Martinez-Fernandez L., Improta R.
openaire   +3 more sources

An enzymatic assay for high-throughput screening of cytidine-producing microbial strains.

PLoS ONE, 2015
Cytidine is an industrially useful precursor for the production of antiviral compounds and a variety of industrial compounds. Interest in the microbial production of cytidine has grown recently and high-throughput screening of cytidine over-producers is ...
Huina Dong, Yongfei Liu, Xin Zu, Ning Li, Feiran Li, Dawei Zhang   +5 more
doaj   +1 more source

Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice

Crop Journal, 2020
The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3 (BE3) and targeted activation-induced ...
Ruiying Qin, Shengxiang Liao, Juan Li, Hao Li, Xiaoshuang Liu, Jianbo Yang, Pengcheng Wei   +6 more
doaj   +1 more source

Potential SARS-CoV-2 RdRp inhibitors of cytidine derivatives: Molecular docking, molecular dynamic simulations, ADMET, and POM analyses for the identification of pharmacophore sites.

PLoS ONE, 2022
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one of the optimum targets for antiviral drug design and development. The hydroxyl groups of cytidine structures were modified with different aliphatic and aromatic groups to obtain 5´-O-acyl and 2´
Sarkar M A Kawsar, Mohammed A Hosen, Sajjad Ahmad, Youness El Bakri, Hamid Laaroussi, Taibi Ben Hadda, Faisal A Almalki, Yasuhiro Ozeki, Souraya Goumri-Said   +8 more
doaj   +2 more sources

Construction of a cytidine base editor based on Exopalaemon carinicauda cytidine deaminase and its application in crustacean genome editing

Aquaculture Reports, 2022
Economic crustaceans play important roles in aquaculture and create great benefits for the world agricultural economy. Studies have found that there are many single nucleotide polymorphism (SNP) sites in the crustacean genomes, which closely related to a
Yujie Liu, Kefan Xing, Zixuan Wu, Congcong Yan, Yuying Sun, Jiquan Zhang   +5 more
doaj   +1 more source