Results 1 to 10 of about 42,535 (254)
Cytosine Methylation Affects the Mutability of Neighboring Nucleotides in Germline and Soma [PDF]
Genetics, 2020 Abstract Methylated cytosines deaminate at higher rates than unmethylated cytosines, and the lesions they produce are repaired less efficiently. As a result, methylated cytosines are mutational hotspots. Here, combining rare polymorphism and base-resolution methylation data in humans, Arabidopsis thaliana, and rice (Oryza sativa), we ...
Magdalena Drozdz +2 more
exaly +4 more sources
Sequence context and methylation interact to shape germline mutation rate variation at CpG sites. [PDF]
PLoS GeneticsA prominent example of sequence context-dependent mutation rate variation is the elevated transition rate at CpG sites, which is largely attributed to cytosine methylation.
Sheel Chandra, Ziyue Gao
doaj +2 more sources
4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y<sub>6</sub> receptor. [PDF]
Medchemcomm, 2013 4-Alkyloxyimino derivatives of pyrimidine nucleotides display high potency as agonists of certain G protein-coupled P2Y receptors (P2YRs). In an effort to functionalize a P2Y6R agonist for fluorescent labeling, we probed two positions (N4 and γ-phosphate of cytidine derivatives) with various functional groups, including alkynes for click chemistry ...
Jayasekara PS +9 more
europepmc +4 more sources
Frontiers in Genetics, 2023 Introduction: Essential genes are essential for the survival of various species. These genes are a family linked to critical cellular activities for species survival.
Ranjeet Kumar Rout +7 more
doaj +1 more source
Nucleotide discrimination with DNA immobilized in the MspA nanopore. [PDF]
PLoS ONE, 2011 Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction.
Elizabeth A Manrao +4 more
doaj +1 more source
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
Nature Communications, 2021 Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ...
Hongxu Ding +4 more
doaj +1 more source
A CNN based m5c RNA methylation predictor
Scientific Reports, 2023 Post-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation.
Irum Aslam +6 more
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BMC Research Notes, 2022 Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj +1 more source
AMB Express, 2020 The giant mottled eel is a species with high commercial value so overfishing, river management, and water pollution have negatively affected its movement and population numbers. Anguilla marmorata (eel) was listed in the Vietnam Red Data Book 2007 with a
Kieu Thi Huyen, Nguyen Quang Linh
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Expression of microRNAs in Horse Plasma and Their Characteristic Nucleotide Composition. [PDF]
PLoS ONE, 2016 MicroRNAs (miRNAs) in blood plasma are stable under high levels of ribonuclease activity and could function in tissue-to-tissue communication, suggesting that they may have distinctive structural characteristics compared with non-circulating miRNAs.
Seungwoo Lee +7 more
doaj +1 more source