Results 21 to 30 of about 42,535 (254)

Vibrational Spectra of Nucleotides in the Presence of the Au Cluster Enhancer in MD Simulation of a SERS Sensor

Biosensors, 2021
Surface-enhanced Raman scattering (SERS) nanoprobes have shown tremendous potential in in vivo imaging. The development of single oligomer resolution in the SERS promotes experiments on DNA and protein identification using SERS as a nanobiosensor.
Tatiana Zolotoukhina, Momoko Yamada, Shingo Iwakura   +2 more
doaj   +1 more source

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain [PDF]

PLOS Genetics, 2017
Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the classical MeCP2 DNA recognition sequence, but additional methylated sequence targets have been reported.
Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Bird   +11 more
openaire   +6 more sources

SERS Studies of Adsorption on Gold Surfaces of Mononucleotides with Attached Hexanethiol Moiety: Comparison with Selected Single-Stranded Thiolated DNA Fragments

Molecules, 2019
The attachment of DNA strands to gold surfaces is performed in many devices, such as various DNA sensors. One of the standard methods used to immobilize DNA on gold surfaces involves two steps: the attachment of a thiol linker group (usually in the form ...
Edyta Pyrak, Aleksandra Jaworska, Andrzej Kudelski   +2 more
doaj   +1 more source

Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA

BioTechniques, 2010
DNA cytosine methylation (5mC) is highly abundant in mammalian cells and is associated with transcriptional repression. Recently, hydroxymethylcytosine (hmC) has been detected at high levels in certain human cell types; however, its roles are unknown ...
Colm Nestor, Alexey Ruzov, Richard R. Meehan, Donncha S. Dunican   +3 more
doaj   +1 more source

Sequencing and Analysis of the Genome of Propionibacterium freudenreichii T82 Strain: Importance for Industry

Biomolecules, 2020
The genome of Propionibacterium freudenreichii ssp. freudenreichii T82, which has a chromosome containing 2,585,340 nucleotides with 67.3% GC content (guanine-cytosine content), is described in this paper. The total number of genes is 2308, of which 2260
Kamil Piwowarek, Edyta Lipińska, Elżbieta Hać-Szymańczuk, Marek Kieliszek, Anna Maria Kot   +4 more
doaj   +1 more source

Identification of a Novel Mitochondrial DNA Sequence Variation within the Human Mitochondrial DNA Control Region in a Population of Aegean Population

Erciyes Medical Journal, 2019
Objective: Environmental impacts, history as well as established cultural regulations, and many more other factors had shaped broadly diverse structure of human genetic patterns.
Aylin Köseler, Sehime Gülsün Temel, Mahmut Cerkez Ergoren   +2 more
doaj   +1 more source

Research progress of dCTP pyrophosphatase 1 regulating nucleotide metabolism and phenotype of tumor cells [PDF]

Jichu yixue yu linchuang, 2021
Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP).
LI Jing, ZHANG Mei-gui, BAI Zhong-tian
doaj  

Comparative review on left-handed Z-DNA

Frontiers in Bioscience-Landmark, 2021
Being polymorphic, deoxyribonucleic acid is worthy of raise a variety of structure like right-handed B to left-handed Z conformation. In left-handed contour of DNA consecutive nucleotides substitute between syn-arrangement and anti-arrangement, through ...
Reetabrita Roy, Pallab Chakraborty, Arindam Chatterjee, Joy Sarkar   +3 more
doaj   +1 more source

Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G [PDF]

PeerJ, 2017
APOBEC3A and APOBEC3G cytidine deaminases inhibit viruses and endogenous retrotransposons. We recently demonstrated the novel cellular C-to-U RNA editing function of APOBEC3A and APOBEC3G.
Shraddha Sharma, Bora E. Baysal
doaj   +2 more sources

A New Specific and Sensitive RT-qPCR Method Based on Splinted 5′ Ligation for the Quantitative Detection of RNA Species Shorter than microRNAs

Non-Coding RNA, 2021
Recently, we discovered a new family of unusually short RNAs mapping to 5.8S ribosomal RNA (rRNA) and which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members contain.
Marine Lambert, Abderrahim Benmoussa, Patrick Provost   +2 more
doaj   +1 more source