Pseudouridines and Pseudouridine Synthases of the Ribosome
Cold Spring Harbor Symposia on Quantitative Biology, 2001 psi are ubiquitous in ribosomal RNA. Eubacteria, Archaea, and eukaryotes all contain psi, although their number varies widely, with eukaryotes having the most. The small ribosomal subunit can apparently do without psi in some organisms, even though others have as many as 40 or more.
J, Ofengand +7 more
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Ribosomal RNA pseudouridines and pseudouridine synthases [PDF]
FEBS Letters, 2002 Pseudouridines are found in virtually all ribosomal RNAs but their function is unknown. There are four to eight times more pseudouridines in eukaryotes than in eubacteria. Mapping 19 Haloarcula marismortui pseudouridines on the three‐dimensional 50S subunit does not show clustering.
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Metabolic Engineering of Escherichia coli for Efficient Production of Pseudouridine
, 2023 Pseudouridine-incorporated mRNA vaccines can enhance protein expression and reduce immunogenicity, leading to a high demand for pseudouridine to be used in mRNA drug production.
Liyuan Wei (7216439) +9 more
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The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
Frontiers in Cell and Developmental Biology, 2021 The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide.
Pedro Morais, Hironori Adachi, Yi-Tao Yu
doaj +1 more source
tRNA Modifications: Impact on Structure and Thermal Adaptation
Biomolecules, 2017 Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules between the informational level of nucleic acids and the functional level of proteins.
Christian Lorenz +2 more
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The regulation of antiviral innate immunity through non-m6A RNA modifications
Frontiers in Immunology, 2023 The post-transcriptional RNA modifications impact the dynamic regulation of gene expression in diverse biological and physiological processes. Host RNA modifications play an indispensable role in regulating innate immune responses against virus infection
Shenghai Shen +2 more
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Data_Sheet_1_Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK.PDF
, 2022 Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Wenting Guo (800486) +5 more
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Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine
Molecules, 2020 We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year.
William H. Gmeiner
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The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA [PDF]
, 2010 The Nep1 (Emg1) SPOUT-class methyltransferase is an essential ribosome assembly factor and the human Bowen–Conradi syndrome (BCS) is caused by a specific Nep1D86G mutation. We recently showed in vitro that Methanocaldococcus jannaschii Nep1 is a sequence-
Valeska Schilling +27 more
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