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An investigation into eukaryotic pseudouridine synthases [PDF]
Journal of Bioinformatics and Computational Biology, 2014 A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudouridine. We investigated the biological significance of eukaryotic pseudouridine synthases using the yeast Saccharomyces cerevisiae. We conducted a comprehensive statistical analysis on growth data from automated perturbation (gene deletion) experiments,
Ross D. King, Chuan Lu
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Blood Plasma Pseudouridine in Patients with Malignant Proliferative Diseases1) [PDF]
, 1993 Summary: The blood plasma concentration of pseudouridine was estimated in 104 healthy adult subjects, and 108 patients suffering from malignant proliferative diseases.
Daniewska-Michalska, Dorota +17 more
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Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens
Vaccines, 2021 Nucleic acid-based influenza vaccines are a promising platform that have recently and rapidly developed. We previously demonstrated the immunogenicity of DNA vaccines encoding artificial immunogens AgH1, AgH3, and AgM2, which contained conserved ...
Ekaterina V. Starostina +14 more
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Spliceosomal snRNA Epitranscriptomics
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Structure and function of pseudouridine synthases
, 2004 Pseudouridine (the 5-ribosyl isomer of uridine) is the single most abundant post-transcriptional modification found in the stable, structured RNAs (ribosomal, transfer, small nuclear, and small nucleolar) of all organisms.
Del Campo, Mark
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Recent Advances in Identification of RNA Modifications
Non-Coding RNA, 2016 RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions.
Wei Chen, Hao Lin
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Pseudouridines of tRNA Anticodon Stem-Loop Have Unexpected Role in Mutagenesis in Pseudomonas sp.
Microorganisms, 2020 Pseudouridines are known to be important for optimal translation. In this study we demonstrate an unexpected link between pseudouridylation of tRNA and mutation frequency in Pseudomonas species.
Mari Tagel +5 more
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H/ACA Small Ribonucleoproteins: Structural and Functional Comparison Between Archaea and Eukaryotes
Frontiers in Microbiology, 2021 During ribosome synthesis, ribosomal RNA is modified through the formation of many pseudouridines and methylations which contribute to ribosome function across all domains of life.
Dominic P. Czekay, Ute Kothe
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Pseudouridine Synthase RsuA Confers a Survival Advantage to Bacteria under Streptomycin Stress
Antibiotics, 2023 Bacterial ribosome small subunit rRNA (16S rRNA) contains 11 nucleotide modifications scattered throughout all its domains. The 16S rRNA pseudouridylation enzyme, RsuA, which modifies U516, is a survival protein essential for bacterial survival under ...
Sudeshi M. Abedeera +4 more
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, 2015 It has long been known that pseudouridine (Ψ) is the most abundant modified nucleotide in stable RNAs, including tRNA, rRNA, and snRNA. Recent studies using massive parallel sequencing have uncovered the presence of hundreds of Ψs in mRNAs as well.
Guowei, Wu, Chao, Huang, Yi-Tao, Yu
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