Results 51 to 60 of about 1,806,143 (218)
Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches
Molecular Therapy: Nucleic Acids, 2019 mRNA therapeutics hold great promise for the treatment of human diseases. While incorporating naturally occurring modified nucleotides during synthesis has greatly increased their potency and safety, challenges in selective expression have hindered ...
John Lockhart +4 more
doaj +1 more source
Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, EarlyView.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
Penguin: A tool for predicting pseudouridine sites in direct RNA nanopore sequencing data [PDF]
, 2022 Pseudouridine is one of the most abundant RNA modifications, occurring when uridines are catalyzed by Pseudouridine synthase proteins. It plays an important role in many biological processes and also has an importance in drug development.
Acevedo, Daniel +5 more
core +1 more source
Guide snoRNAs: Drivers or Passengers in Human Disease?
Biology, 2018 In every domain of life, RNA-protein interactions play a significant role in co- and post-transcriptional modifications and mRNA translation. RNA performs diverse roles inside the cell, and therefore any aberrancy in their function can cause various ...
Manisha Deogharia, Mrinmoyee Majumder
doaj +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Urinary pseudouridine excretion in myelomatosis [PDF]
British Journal of Cancer, 1985 Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol. mumol ucr-1 in controls.
S H, Sørensen +4 more
openaire +2 more sources
Synthesis of 15N-Enriched Pseudouridine Derivatives
, 2016 A procedure for the chemical synthesis of [3-15N]-labeled pseudouridine and a methylated derivative was developed. A suitably protected pseudouridine precursor was nitrated at N3 followed by treatment with 15NH4Cl to afford the 15N-labeled product in six
Christine S. Chow (2082214) +2 more
core +1 more source
PLoS ONEPseudouridine is an important modification site, which is widely present in a variety of non-coding RNAs and is involved in a variety of important biological processes.
Bo Han +5 more
doaj +1 more source
BiologyRNA pseudouridine modification exists in different RNA types of many species, and it has a significant role in regulating the expression of biological processes.
Xiao Wang, Pengfei Li, Rong Wang, Xu Gao
doaj +1 more source
Deciphering transcriptome complexity via long‐read sequencing
iMeta, EarlyView.Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu +21 more
wiley +1 more source