Results 41 to 50 of about 1,745,918 (176)
A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation [PDF]
The Plant Cell, 2020 Pseudouridine (Ψ) is a frequent nucleoside modification that occurs in both noncoding RNAs and mRNAs. In pseudouridine, C5 of uracil is attached to the Rib via an unusual C-glycosidic bond. This RNA modification is introduced on the RNA by site-specific transglycosylation of uridine (U), a process mediated by pseudouridine synthases.
Mingjia Chen, Claus-Peter Witte
openaire +2 more sources
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
PUS7 Deficiency: Phenotypical Expansion of PUS7‐Related Neurodevelopmental Disorders
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Pathogenic variants in PUS7, encoding pseudouridine synthase 7, cause a rare neurodevelopmental disorder marked by intellectual disability, microcephaly, short stature, and behavioral disturbances. Since the first report in 2018, only 16 patients have been described.
Alice Muda +5 more
wiley +1 more source
Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, EarlyView.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
Current Issues in Molecular Biology, 2021 RNA pseudouridine modification is particularly important in a variety of cellular biological and physiological processes. It plays a significant role in understanding RNA functions, RNA structure stabilization, translation processes, etc.
Xiao Wang +6 more
doaj +1 more source
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination
Allergy, EarlyView.We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera +14 more
wiley +1 more source
Pseudouridine Metabolism. IV. Excretion of Pseudouridine and Other Nitrogenous Metabolites in Chronic Leukemia [PDF]
Blood, 1963 Abstract Urinary pseudouridine, uric acid, and creatine have been estimated in a group of patients with chronic lymphocytic leukemia, chronic myelogenous leukemia, and other diseases. The results indicate that there is a selective and specific overproduction of pseudouridine in patients with chronic lymphocytic leukemia.
S M, WEISSMAN, M, LEWIS, M, KARON
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi +13 more
wiley +1 more source