Results 41 to 50 of about 1,806,143 (218)
Pseudouridine synthases are proviral factors for Sindbis virus in insect and mammalian cells
mBioAlphaviruses are positive-sense, single-stranded RNA (+ssRNA) viruses transmitted by arthropod vectors to vertebrate hosts. Pseudouridine is the most prevalent RNA modification in the prototype alphavirus, Sindbis virus (SINV) genome, but the location ...
Nicole Stark +6 more
doaj +1 more source
Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA
Microorganisms, 2018 To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes have been identified not only in thermophiles but also in mesophiles.
Hiroyuki Hori +6 more
doaj +1 more source
Impact of Pus1 Pseudouridine Synthase on Specific Decoding Events in Saccharomyces cerevisiae
Biomolecules, 2020 Pus1-dependent pseudouridylation occurs in many tRNAs and at multiple positions, yet the functional impact of this modification is incompletely understood.
Bahar Khonsari, Roland Klassen
doaj +1 more source
Advanced Science, EarlyView.Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation [PDF]
The Plant Cell, 2020 Pseudouridine (Ψ) is a frequent nucleoside modification that occurs in both noncoding RNAs and mRNAs. In pseudouridine, C5 of uracil is attached to the Rib via an unusual C-glycosidic bond. This RNA modification is introduced on the RNA by site-specific transglycosylation of uridine (U), a process mediated by pseudouridine synthases.
Mingjia Chen, Claus-Peter Witte
openaire +2 more sources
Frontiers in Cell and Developmental BiologyType 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and progressive β-cell dysfunction.
Marketa Hlavackova +8 more
doaj +1 more source
Molecular identification of pseudouridine-metabolizing enzymes
, 2008 Pseudouridine, a non-classical nucleoside present in human urine as a degradation product of RNAs, is one of the few molecules that has a glycosidic C-C bond.
Snoussi, Karim +4 more
core +1 more source
애기장대 유래 Pseudouridine Kinase의 구조와 생화학적 기능 분석 [PDF]
, 2021 학위논문(박사) -- 서울대학교대학원 : 농업생명과학대학 농생명공학부, 2021.8. 이상기.RNA의 변형은 종류가 매우 다양하며 각각 RNA들의 안정성, mRNA와 단백질들간의 상호작용 그리고 단백질로의 번역과정에 효율성을 조절하는 등 다양한 역할을 담당한다. 대부분의 경우, RNA의 변형은 효소들에 의해서 특정 RNA에 부위 특이적으로 일어난다.
김상훈
core
N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Scientific Reports, 2022 AbstractIn vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N1-methyl-pseudouridine (m1Ψ), are incorporated in the synthetic mRNA.
Tien-Hao Chen +4 more
openaire +3 more sources
Identification of molecular subtypes based on pseudouridine modification in hepatocellular carcinoma
Cancer Cell InternationalHepatocellular carcinoma (HCC) is a highly aggressive disease with a dismal prognosis. The recently described role of RNA pseudouridine modification in regulating anti-tumor immunity has attracted interest, but the understanding of its impact on ...
Weifeng Xu +12 more
doaj +1 more source