Results 61 to 70 of about 1,745,918 (176)
Molecular Therapy: Nucleic AcidsNucleoside-modified messenger RNA (mRNA) technologies necessarily incorporate N1-methylpseudouridine into the mRNA molecules to prevent the over-stimulation of cytoplasmic RNA sensors.
Esteban Finol +4 more
doaj +1 more source
Stabilization of RNA stacking by pseudouridine [PDF]
Nucleic Acids Research, 1995 The effect of the modified nucleoside pseudouridine (psi) on RNA structure was compared with uridine. The extent of base stacking in model RNA oligonucleotides was measured by 1H NMR, UV, and CD spectroscopy. The UV and CD results indicate that the model single-stranded oligoribonucleotides AAUA and AA psi A form stacked structures in solution and the ...
openaire +2 more sources
GK PUA Domain Modulates Cables, Cooperativity, and Proline Feedback
Aggregate, Volume 7, Issue 8, August 2026.EcGK tetramers hierarchically assemble into metabolic filaments and bundle into metabolic cables. Upon substrate binding, this dynamic equilibrium shifts from inactive cables to active tetramers to drive catalysis; meanwhile the inhibitor proline stabilizes an X‐shaped conformation, redirecting assembly toward filaments to enable efficient feedback ...
Tianyi Zhang +4 more
wiley +1 more source
A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates
Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm +3 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.Major symptoms of dyskeratosis congenita. Predicted nuclear localization site at N‐terminus of DKC1 protein. Comparison of nuclear localization for DKC1 showing normal localization for wild‐type versus disruption of localization for p.Ala2Val. ABSTRACT Background Dyskeratosis congenita (DKC) is typically characterized by the triad of abnormal cutaneous
Taimoor I. Sheikh, John B. Vincent
wiley +1 more source
Agricultural and Food Science, 1998 The potential of the spot urine sampling technique to assess urinary pseudouridine excretion was evaluated. Twelve multiparous Holstein-Friesian cows were fed two experimental diets in a complete change-over design with two 14 day experimental periods ...
Kevin J. Shingfield, Nicholas W. Offer
doaj
The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders
Frontiers in Bioengineering and Biotechnology, 2018 Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression ...
Margarita T. Angelova +6 more
doaj +1 more source
Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess +1 more
wiley +1 more source
Agricultural and Food Science, 2008 The potential of the spot urine sampling technique to assess urinary pseudouridine excretion was evaluated. Twelve multiparous Holstein-Friesian cows were fed two experimental diets in a complete change-over design with two 14 day experimental periods ...
K. SHINGFIELD, N.W. OFFER
doaj
A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach
Molecules, 2018 An in silico study has been conducted upon (3′RS,5′SR)-5-[2′-benzyl-5′-hydroxymethyl-1′,2′-isoxazolidin-3′-yl]uracil through a molecular dynamics/docking approach that highlights its potential inhibitory activity upon the wild-type pseudouridine 5 ...
Giuseppe Floresta +7 more
doaj +1 more source