Pseudouridine Synthase 7 in Cancer: Functions, Mechanisms, and Therapeutic Potential [PDF]
CellsPseudouridylation, the most abundant RNA modification, plays a critical role in modulating RNA structure, stability, and function. Among the family of pseudouridine synthases, Pseudouridine Synthase 7 (PUS7) has recently gained attention for its emerging
Qiwei Yang +2 more
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Pseudouridine Synthase RsuA Captures an Assembly Intermediate That Is Stabilized by Ribosomal Protein S17 [PDF]
Biomolecules, 2020 The ribosome is a large ribonucleoprotein complex that synthesizes protein in all living organisms. Ribosome biogenesis is a complex process that requires synchronization of various cellular events, including ribosomal RNA (rRNA) transcription, ribosome ...
Sanjaya Abeysirigunawardena
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Pseudouridine synthase 1 promotes progression of hepatocellular carcinoma via mTOR and MYC signaling pathways [PDF]
Frontiers in OncologyPseudouridine synthases (PUSs) are associated with the development and progression of various cancers. However, the role of pseudouridine synthase 1 (PUS1) on HCC is unclear.
Yonghuang Tan, Yong Mei
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Pseudouridine Synthase RsuA Confers a Survival Advantage to Bacteria under Streptomycin Stress [PDF]
Antibiotics, 2023 Bacterial ribosome small subunit rRNA (16S rRNA) contains 11 nucleotide modifications scattered throughout all its domains. The 16S rRNA pseudouridylation enzyme, RsuA, which modifies U516, is a survival protein essential for bacterial survival under ...
Sanjaya Abeysirigunawardena +2 more
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RluA is the major mRNA pseudouridine synthase in Escherichia coli. [PDF]
PLoS GeneticsPseudouridine (Ψ) is an ubiquitous RNA modification, present in the tRNAs and rRNAs of species across all domains of life. Conserved pseudouridine synthases modify the mRNAs of diverse eukaryotes, but the modification has yet to be identified in ...
Cassandra Schaening-Burgos +4 more
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The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1 [PDF]
PLoS ONE, 2023 The chemical modification of RNA bases represents a ubiquitous activity that spans all domains of life. Pseudouridylation is the most common RNA modification and is observed within tRNA, rRNA, ncRNA and mRNAs.
Sebastian Grünberg +6 more
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Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance [PDF]
Nature CommunicationsPseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It is widely speculated that Ψ inclusion in messenger RNAs (mRNAs) might provide an avenue for cells to control gene expression post-transcriptionally ...
Minli Ruan +15 more
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Impact of Pus1 Pseudouridine Synthase on Specific Decoding Events in Saccharomyces cerevisiae [PDF]
Biomolecules, 2020 Pus1-dependent pseudouridylation occurs in many tRNAs and at multiple positions, yet the functional impact of this modification is incompletely understood.
Bahar Khonsari, Roland Klassen
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Higher expression of pseudouridine synthase 7 promotes non-small cell lung cancer progression and suggests a poor prognosis [PDF]
Journal of Cardiothoracic Surgery, 2023 Background Lung cancer is currently the second most common cancer, and non-small cell lung cancer accounts for about 85% of cases. NSCLC has not been studied for pseudouridine synthase 7 (PUS), a member of the PUS family that is associated with cancer ...
Guihong Zhang +6 more
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Pseudouridine synthase PUS1 and initiation factor mtIF2 are human mitoribosomal small subunit assembly factors [PDF]
Nature CommunicationsAssembly of the mitochondrial ribosome (mitoribosome) is a crucial step in mitochondrial gene expression. This process facilitates mitochondrial translation, which produces essential subunits of the oxidative phosphorylation machinery—the cell’s primary ...
Vivek Singh +4 more
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