Results 31 to 40 of about 431,100 (179)
Pseudouridine synthase 7 impacts Candida albicans rRNA processing and morphological plasticity [PDF]
Yeast, 2019 Douglas A Bernstein, Munni Begum
exaly +2 more sources
mRNA structure determines modification by pseudouridine synthase 1. [PDF]
Nat Chem Biol, 2019 Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. Messenger RNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms responsible for selective, regulated pseudouridylation of specific sequences within mRNAs were ...
Carlile TM +6 more
europepmc +4 more sources
An investigation into eukaryotic pseudouridine synthases [PDF]
Journal of Bioinformatics and Computational Biology, 2014 A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudouridine. We investigated the biological significance of eukaryotic pseudouridine synthases using the yeast Saccharomyces cerevisiae. We conducted a comprehensive statistical analysis on growth data from automated perturbation (gene deletion) experiments,
Ross D. King, Chuan Lu
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Cloning and characterization of a mammalian pseudouridine synthase [PDF]
RNA, 1999 This report describes the cloning and characterization of a pseudouridine (psi) synthase from mouse that we have named mouse pseudouridine synthase 1 (mpus1p). The cDNA is approximately 1.5 kb and when used as a probe on a Northern blot of mouse RNA from tissues and cultured cells, several bands were detected.
J, Chen, J R, Patton
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Critical Aspartic Acid Residues in Pseudouridine Synthases [PDF]
Journal of Biological Chemistry, 1999 The pseudouridine synthases catalyze the isomerization of uridine to pseudouridine at particular positions in certain RNA molecules. Genomic data base searches and sequence alignments using the first four identified pseudouridine synthases led Koonin (Koonin, E. V. (1996) Nucleic Acids Res.
V, Ramamurthy +4 more
openaire +2 more sources
Characterization of the Pseudouridine Synthase TruD Family [PDF]
, 2013 RNA contains over 100 post-transcriptional chemical modifications. Of these, the most abundant is pseudouridine (Ψ), the 5’ ribosyl isomer of uridine. The formation of Ψ occurs at the polynucleotide level, and is catalyzed by Ψ synthase enzymes.
Recinos, Claudia
core +3 more sources
The Role of Cysteine Residues in the Rearrangement of Uridine to Pseudouridine Catalyzed by Pseudouridine Synthase I [PDF]
Journal of Biological Chemistry, 1997 Escherichia coli tRNA pseudouridine synthase I (PSUI) catalyzes the conversion of uridine residues to pseudouridine in positions 38, 39, and 40 of various tRNA molecules. In previous biochemical studies with this enzyme (Kammen, H. O., Marvel, C. C., Hardy, L., and Penhoet, E. E. (1988) J. Biol. Chem.
X, Zhao, D A, Horne
openaire +2 more sources
Epitranscriptomics of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2022 Recent studies on the epitranscriptomic code of SARS-CoV-2 infection have discovered various RNA modifications, such as N6-methyladenosine (m6A), pseudouridine (Ψ), and 2′-O-methylation (Nm).
Amin Izadpanah +4 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: The pseudouridine synthases (PUSs) have been reported to be associated with cancers. However, their involvement in hepatocellular carcinoma (HCC) has not been well documented.
Zhipeng Jin +6 more
doaj +1 more source
Chemistry & Biology, 2006 Pseudouridine synthases are the enzymes responsible for the most abundant posttranscriptional modification of cellular RNAs. These enzymes catalyze the site-specific isomerization of uridine residues that are already part of an RNA chain, and appear to employ both sequence and structural information to achieve site specificity.
Hamma, Tomoko +1 more
openaire +2 more sources