Multi-omics analysis identifies PUS7 as an immune modulator driving NETs-mediated macrophage polarization in pancreatic cancer [PDF]
Clinical and Translational MedicinePseudouridine synthases (PUS) have been implicated in various cancers, yet their roles in pancreatic cancer immunity remain unclear. Through integrative multi‐omics analyses combining genomics, transcriptomics, and clinical datasets, we evaluated ...
Chuanzhao Zhang +2 more
exaly +7 more sources
HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells [PDF]
Scientific ReportsThe metastasis and chemotherapy resistance of gastric cancer significantly contribute to treatment failure and mortality. Based on previous studies, we hypothesized that Heat Shock Protein 90 (HSP90) interacts with and upregulates Pseudouridine Synthase ...
Guoyan Liu, Qi Li, Chenchun Ding
exaly +5 more sources
Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation [PDF]
Nature CommunicationsPseudouridine (Ψ) is a widespread RNA modification in various RNA species, including rRNA, tRNA, snRNA and mRNA. Ψ plays a crucial role in RNA metabolism, where it regulates pre-mRNA splicing and affects protein translation.
Shun Liu, Tong Wu, Cheng-Wei Ju
exaly +5 more sources
PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression [PDF]
Clinical and Translational MedicineBackground RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions.
Yongxia Chang
exaly +5 more sources
PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation [PDF]
Molecular BrainRNA modifications serve as dynamic regulators of neural plasticity through their ability to fine-tune transcript stability and splicing. Pseudouridine (Ψ), an evolutionarily conserved RNA modification catalyzed by pseudouridine synthases, plays ...
Jichun Shi, Ziyue Xu
exaly +5 more sources
Identification and Characterization of the RNA Modifying Factors PUS7 and WTAP as Key Components for the Control of Tumor Biological Processes in Renal Cell Carcinomas [PDF]
Current Issues in Molecular BiologyCurrent research discusses the putative importance of RNA modification in tumor diseases. These RNA modifications include predominantly pseudouridinylation, ortho-methylations on the ribose residues, as well as methylations on the organic bases.
Simon Jasinski-Bergner +2 more
exaly +6 more sources
HSP90-dependent PUS7 overexpression facilitates the metastasis of colorectal cancer cells by regulating LASP1 abundance [PDF]
Journal of Experimental and Clinical Cancer Research, 2021 Background Pseudouridine synthase (PUS) 7 is a member of the PUS family that catalyses pseudouridine formation. It has been shown to be involved in intellectual development and haematological malignancies.
Li Zheng-Yan, Qingchuan Zhao, Kaichun Wu
exaly +4 more sources
The pseudouridine synthase PUS7 is associated with stemness and represents a potential therapeutic target in triple-negative breast cancer cells [PDF]
Scientific ReportsTriple-negative breast cancer (TNBC) represents a highly aggressive subtype of breast cancer characterized by increased recurrence rates and poor prognosis, primarily due to the lack of effective therapeutic targets.
Lu Lu +4 more
doaj +4 more sources
Molecular Therapy - Nucleic Acids, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive single-stranded RNA virus, engages in complex interactions with host cell proteins throughout its life cycle. While these interactions enable the host to recognize and inhibit viral
Gian Gaetano Tartaglia
exaly +8 more sources
Cytoplasmic localization of pseudouridine synthase 7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance [PDF]
Nature CommunicationsPseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It is widely speculated that Ψ inclusion in messenger RNAs (mRNAs) might provide an avenue for cells to control gene expression post-transcriptionally ...
Minli Ruan +15 more
doaj +2 more sources