Results 41 to 50 of about 883 (101)

Dysregulated ribosome quality control in human diseases

The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.
Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr, Okan Onar, Seyed Mehdi Jafarnejad   +2 more
wiley   +1 more source

Tyrosine transfer RNA levels and modifications during blood‐feeding and vitellogenesis in the mosquito, Aedes aegypti

Insect Molecular Biology, Volume 34, Issue 1, Page 65-80, February 2025.
Blood‐feeding causes shifts in tRNA modification levels and tRNA‐modifying enzyme expression in the mosquito, Aedes aegypti. Identification of mannosyl‐queuosine (manQ) as wobble position modification in tyrosine tRNA in mosquitoes. In the fat body, tyrosine tRNA levels are elevated post blood‐feeding and correlate with the enrichment of tyrosine ...
Melissa Kelley, Christopher J. Holmes, Cassandra Herbert, Asif Rayhan, Judd Joves, Melissa Uhran, Lucas Klaus, Ronja Frigard, Khwahish Singh, Patrick A. Limbach, Balasubrahmanyam Addepalli, Joshua B. Benoit   +11 more
wiley   +1 more source

RNA modifications in cancer

MedComm, Volume 6, Issue 1, January 2025.
This review highlights the pivotal roles of key RNA modifications (m1A, m5C, m6A, m7G, ψ, and I) in cancer progression. These modifications influence tumor proliferation, metastasis, and programmed cell death, while also affecting the immune microenvironment.
Han Wu, Shi Chen, Xiang Li, Yuyang Li, He Shi, Yiwen Qin, Bohe Shi, Yifei Tang, Zhuoyi Yan, Yang Hao, Dongxu Wang, Weiwei Liu   +11 more
wiley   +1 more source

The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies

Ibrain, Volume 10, Issue 4, Page 395-426, Winter 2024.
This review elucidates the pivotal role of RNA modifications in the etiology and progression of neurodegenerative disorders. RNA modification proteins (RMPs) including FTO, HNRNPA2B1, ADAR1/2, METTL3/14, NSUN2, and ALKBH5 are implicated in initiating dysregulated RNA modifications, thereby disrupting RNA metabolism.
Muhammad Abu Talha Safdar Hashmi, Hooriya Fatima, Sadia Ahmad, Amna Rehman, Fiza Safdar   +4 more
wiley   +1 more source

Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance

ABSTRACT Pseudouridine (Ψ) is an abundant post-transcriptional modification found across all classes of RNA. It has been widely speculated that Ψ inclusion in mRNAs might provide an avenue for cells to control gene expression post-transcriptionally.
Minli Ruan, Sean M. Engels, Matthew R. Burroughs, Xiaoyan Li, Rosella Stower, Talia Tzadikario, Connor Powell, Dylan Bloch, Oleksandra Fanari, Stuart Akeson, Daniel E. Eyler, Chase A. Weidmann, Sara Rouhanifard, Miten Jain, Lydia M. Contreras, Kristin S. Koutmou   +15 more
openaire   +2 more sources

Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Advanced Science, Volume 11, Issue 44, November 26, 2024.
Post‐translational modifications (PTMs) of RNA‐modifying proteins, such as METTL3 and METTL14, modulate their activity and interactions, impacting transcription, signaling pathways, and immune responses. These processes are crucial in driving cancer progression, immune evasion, and pathogen responses, making PTMs of RNA modifiers potential therapeutic ...
Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Yucheng Zheng, Xiangyu Huang, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Comparative genome-wide association study on body weight in Chinese native ducks using four models

Poultry Science
: The Jinling White duck represents a newly developed breed characterized by a rapid growth rate and a superior meat quality, offering significant economic value and research potential; however, the genetic basis underlying their body weight traits ...
Yuchen Zhang, Chao Jia, Shiwei Li, Sike Wang, Zongliang He, Guansuo Wu, Minli Yu, Yinglin Lu, Debing Yu   +8 more
doaj   +1 more source

Lost in translation: How neurons cope with tRNA decoding

BioEssays, Volume 46, Issue 9, September 2024.
tRNA modifications are involved in the pathophysiology of the nervous system. Their contribution to genetic neurological disorders demands efforts to clarify their implication in translation decoding and in pathways related to protein synthesis quality control, like the unfolded protein response (UPR), ribosome quality control (RQC), and no‐go mRNA ...
Wei Guo, Stefano Russo, Francesca Tuorto
wiley   +1 more source

RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond

Experimental Hematology & Oncology
The chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest with the ...
You-Peng Ding, Cui-Cui Liu, Ke-Da Yu
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source