Results 51 to 60 of about 883 (101)

Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming

Summary Pseudouridine (Ψ) is a prevalent RNA modification found in multiple RNA species. It is deposited by Ψ synthases (Pus) and it can stabilize RNA structures. Patients carrying alterations in the Pus7 gene suffer from developmental delay, intellectual disability, microcephaly ...
Stock M, Angel MG, Witzenberger M, Nowak J, Biela A, Chramiec-Glabik A, Mariano V, Dreos R, Sklias A, Quadroni M, Brümmer A, Gallart-Ayala H, Ivanisevic J, Guex N, Kleenman L, Leidel S, Helm M, Bagni C, Glatt S, Gatfield D, Schwartz S, Roignant J.   +21 more
europepmc   +2 more sources

Nano-Mod-Amp reveals RNA sequence, structural and cell type specific features of pseudouridylation by PUS7

Abstract Pseudouridines are abundant mRNA modifications that can impact splicing, translation, and stability to tune gene expression. PUS7 is one of the major mRNA pseudouridine synthase whose dysregulation leads to neurodevelopmental disorders and cancer, underscoring the critical function of PUS7-dependent pseudouridines.
Rebecca Rodell, Ronit Jain, Hossein Shenasa, Matias Montes, Nicolas Robalin, Stefan Prodic, Eduardo Eyras, Nicole M. Martinez   +7 more
openaire   +3 more sources

From Misdiagnosis to Discovery: Expanding the Spectrum of Spliceosomopathies. [PDF]

Genes (Basel)
Marchetti GB, Cappuccini F, Goisis L, Verduci E, Natacci F, Gervasini C, Massa V, Milani D, Iascone M, Pezzoli L.   +9 more
europepmc   +1 more source

Pseudouridine synthase 7 as a context-specific therapeutic target in cancer. [PDF]

J Pharmacol Exp Ther
Abundiz-Yañez K, Córdova-Bahena L, Salinas-Jazmín N, Trejo-León AJ, Velasco-Velázquez MA.   +4 more
europepmc   +1 more source

The impact of psuedouridine modification on human tRNA. [PDF]

Biochem Soc Trans
Stone Y, Morgan E, Su YH, Kuo CY, Lin TY.   +4 more
europepmc   +1 more source

Emerging Roles of tRNA Modifications in Translational Adaptation of Human Fungal Pathogens. [PDF]

Microorganisms
Zhu Y, Chen J, Li X, Lu L, Zhang Y.
europepmc   +1 more source

Regulation of Translation of ATF4 mRNA: A Focus on Translation Initiation Factors and RNA-Binding Proteins. [PDF]

Cells
Adjibade P, Mazroui R.
europepmc   +1 more source

Decoding human tRNA modifications and crosstalk by enhanced single-read analysis. [PDF]

Genome Biol
Assari M, Chew BJ, Bayat Tork MA, Sobczyk M, Zhu C, Tran HAV, Rudzka D, Zhang W, Pan T.   +8 more
europepmc   +1 more source

Transfer RNA Modifications in the Immune System Participate in Disease Pathogenesis. [PDF]

Int J Mol Sci
Ma X, Gu H, Zhang Y, Jia H, Li P, Wang Y, Wu J, Wu A, Wu J.   +8 more
europepmc   +1 more source

Pseudouridine prevalence in Kaposi's sarcoma-associated herpesvirus transcriptome reveals an essential mechanism for viral replication. [PDF]

Proc Natl Acad Sci U S A
Mottram TJ, Harper KL, Vasconcelos EJR, Whitehouse A.   +3 more
europepmc   +1 more source