Results 1 to 10 of about 3,085 (163)

Molecular Insights into Widespread Pseudouridine RNA Modifications: Implications for Women’s Health and Disease [PDF]

Biology
Pseudouridine (Ψ), the most abundant RNA modification, plays essential roles in shaping RNA structure, stability, and translational output. Beyond cancer, Ψ is dynamically regulated across numerous physiological and pathological contexts—including immune
Qiwei Yang, Ayman Al-Hendy, Thomas G. Boyer   +2 more
doaj   +2 more sources

The pseudouridine epitranscriptomic landscape of advanced prostate cancer therapeutic resistance identifies TIMM17A as a key player [PDF]

Translational Oncology
Background: Resistance to androgen receptor signaling inhibitors (ARSIs) remains a major barrier of advanced prostate cancer (PCa) treatment. While RNA epitranscriptomic modifications are increasingly recognized as key regulators of tumor biology, the ...
Shu Li, Chuanfan Zhong, Yixun Zhang, Guo Chen, Le Zhang, Jiahong Chen, Ronghua Yang   +6 more
doaj   +2 more sources

Integrative analysis of nanopore direct RNA sequencing data reveals a global impact of pseudouridylation on m6A and m5C modifications [PDF]

npj Precision Oncology
RNA modifications play a crucial role in regulating cellular functions. Among the most abundant modifications in the human transcriptome are pseudouridine (Ψ), N6-methyladenosine (m6A), and 5-methylcytosine (m5C).
Mohit Bansal, Anamika Gupta, Jane Ding, Anirban Kundu, Katherine Marlow, Andrew Gibson, Zhangli Su, Sunil Sudarshan, Han-Fei Ding   +8 more
doaj   +2 more sources

Pseudouridine Synthase 7 in Cancer: Functions, Mechanisms, and Therapeutic Potential [PDF]

Cells
Pseudouridylation, the most abundant RNA modification, plays a critical role in modulating RNA structure, stability, and function. Among the family of pseudouridine synthases, Pseudouridine Synthase 7 (PUS7) has recently gained attention for its emerging
Qiwei Yang, Thomas G. Boyer, Ayman Al-Hendy   +2 more
doaj   +2 more sources

CRISPR Disruption of scaRNA1 Reduces Pseudouridylation in Spliceosomal RNA U2 at U89 and Perturbs the Transcriptome in HEK293T Cells [PDF]

Cells
Small Cajal body-associated RNAs (scaRNAs) are essential for biochemical modification of spliceosomal RNAs and spliceosome function. Changes in scaRNA expression level have been associated with developmental issues, including cancer and congenital heart ...
Amanda Gardner-Kay, Lynndy Le, Michael Filla, Nataliya Kibiryeva, James E. O’Brien, Douglas C. Bittel   +5 more
doaj   +2 more sources

Pseudouridylation of 7SK by PUS7 regulates Pol II transcription elongation [PDF]

Nature Communications
Pseudouridine (Ψ) is a widespread RNA modification in various RNA species, including rRNA, tRNA, snRNA and mRNA. Ψ plays a crucial role in RNA metabolism, where it regulates pre-mRNA splicing and affects protein translation.
Yutao Zhao, Hui-Lung Sun, Wenlong Li, Chang Ye, Xiaoyang Dou, Yong Peng, Tong Wu, Pingluan Wang, Cheng-Wei Ju, Shun Liu, Yuhao Zhong, Qing Dai, Kinga Pajdzik, Chuan He   +13 more
doaj   +2 more sources

Turning Uridines around: Role of rRNA Pseudouridylation in Ribosome Biogenesis and Ribosomal Function

Biomolecules, 2018
Ribosomal RNA (rRNA) is extensively edited through base methylation and acetylation, 2′-O-ribose methylation and uridine isomerization. In human rRNA, 95 uridines are predicted to by modified to pseudouridine by ribonucleoprotein complexes sharing ...
Lorenzo Montanaro, Marianna Penzo
exaly   +3 more sources

Quantitative analysis of small RNA pseudouridylation reveals interplay of PUS enzymes in tRNA anticodon stem-loop [PDF]

Nature Communications
Pseudouridine (Ψ) is an abundant modification in small RNA catalyzed by multiple pseudouridine synthases (PUSs). However, the substrate specificity of human PUSs remains elusive.
Wenqing Liu, Yichen Ma, Liping Wang, Bo Lu, Yuyang Dong, Yuan Zhuang, Bo He, Meiling Zhang, Chengqi Yi   +8 more
doaj   +2 more sources

PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression

Clinical and Translational Medicine
Background RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions.
Yongxia Chang
exaly   +2 more sources

Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives [PDF]

Clinical and Translational Medicine
RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing,
Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li   +10 more
doaj   +2 more sources