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Systematic mapping of small nucleolar RNA interactions in human cells [PDF]

RNA Biology
Altered expression of box C/D small nucleolar RNAs (snoRNAs) is implicated in human diseases, including cancer. Box C/D snoRNAs canonically direct site-specific, 2’-O-methylation but the extent to which they participate in other functions remains unclear.
Hywel Dunn-Davies, Tatiana Dudnakova, Jean-Louis Langhendries, Nicholas Watkins, Denis L.J. Lafontaine, David Tollervey   +5 more
doaj   +2 more sources

SnoRNA in Cancer Progression, Metastasis and Immunotherapy Response

Biology, 2021
Small nucleolar RNA (snoRNA) were one of our earliest recognised classes of non-coding RNA, but were largely ignored by cancer investigators due to an assumption that their activities were confined to the nucleolus. However, as full genome sequences have
Jildou Van der werf
exaly   +3 more sources

RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing [PDF]

EMBO Reports
Small nucleolar RNAs (snoRNAs) are a class of eukaryotic non-coding RNA molecules whose precursor transcripts are capped and polyadenylated. However, these end modifications are detrimental to snoRNA function and must be removed, a process typically ...
Valérie Migeot, Yves Mary, Etienne Fafard-Couture, Pierre Lombard, François Bachand, Michelle S Scott, Carlo Yague-Sanz   +6 more
doaj   +2 more sources

CGSDA: inferring snoRNA-disease associations via ChebNetII and GatedGCN [PDF]

Frontiers in Genetics
IntroductionRecent biomedical studies have highlighted the pivotal role of non-coding RNAs (ncRNAs) in gene regulatory networks, where they influence gene expression, cellular function, and the onset and progression of various diseases.
Yongfu Zou, Yusong Lu, Shanghui Lu, Zhanliang Wei, Le Li, Shuilin Liao, Ting Zeng, Yi Zhang, Rui Miao   +8 more
doaj   +2 more sources

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP [PDF]

Genome Biology
Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosomal RNA (snRNA).
Zhuoyi Song, Bongmin Bae, Simon Schnabl, Fei Yuan, Thareendra De Zoysa, Maureen V. Akinyi, Charlotte A. Le Roux, Karine Choquet, Amanda J. Whipple, Eric L. Van Nostrand   +9 more
doaj   +2 more sources

GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings [PDF]

Computational and Structural Biotechnology Journal
Small nucleolar RNAs (snoRNAs) play essential roles in various cellular processes, and their associations with diseases are increasingly recognized.
Massimo La Rosa, Antonino Fiannaca, Isabella Mendolia, Laura La Paglia, Alfonso Urso   +4 more
doaj   +2 more sources

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma [PDF]

Frontiers in Genetics
IntroductionSmall nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression.
Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun   +34 more
doaj   +2 more sources

Prader-Willi syndrome: reflections on seminal studies and future therapies [PDF]

Open Biology, 2020
Prader-Willi syndrome (PWS) is caused by the loss of function of the paternally inherited 15q11-q13 locus. This region is governed by genomic imprinting, a phenomenon in which genes are expressed exclusively from one parental allele.
Michael S. Chung, Maéva Langouët, Stormy J. Chamberlain, Gordon G. Carmichael   +3 more
doaj   +1 more source

snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management

Cells, 2020
Small nucleolar RNAs (snoRNAs) are non-coding RNAs localized in the nucleolus, where they participate in the cleavage and chemical modification of ribosomal RNAs.
Nour-El-Houda Mourksi, Chloé Morin, Tanguy Fenouil, Jean-Jacques Diaz, Virginie Marcel   +4 more
doaj   +1 more source

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis

RNA Biology, 2022
snR30/U17 is a highly conserved H/ACA RNA that is required for maturation of the small ribosomal subunit in eukaryotes. By base-pairing to the expansion segment 6 (ES6) of 18S ribosomal RNA (rRNA), the snR30 H/ACA Ribonucleoprotein (RNP) indirectly ...
Timothy J. Vos, Ute Kothe
doaj   +1 more source