SnoRNA in Cancer Progression, Metastasis and Immunotherapy Response
Biology, 2021 Small nucleolar RNA (snoRNA) were one of our earliest recognised classes of non-coding RNA, but were largely ignored by cancer investigators due to an assumption that their activities were confined to the nucleolus. However, as full genome sequences have
Jildou van der Werf
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Selective remodeling of snoRNA and sdRNA biology in glioblastoma [PDF]
Frontiers in Cell and Developmental BiologySmall nucleolar RNAs (snoRNAs) are best known as guide RNAs for ribosomal RNA modification, but accumulating evidence indicates that their biology extends beyond canonical ribosome maturation.
Hongtao Yin, Meiying Mu, Zhuoqun Wang
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Systematic mapping of small nucleolar RNA interactions in human cells [PDF]
RNA BiologyAltered expression of box C/D small nucleolar RNAs (snoRNAs) is implicated in human diseases, including cancer. Box C/D snoRNAs canonically direct site-specific, 2’-O-methylation but the extent to which they participate in other functions remains unclear.
Hywel Dunn-Davies +5 more
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A small nucleolar RNA dictates the structure and function of translating ribosomes in Leishmania [PDF]
Nature CommunicationsThe most common rRNA modification is 2’-O-methylation. Here, we determine the landscape of 2’-O-methylation in Leishmania, a parasite that cycles between two different hosts, insect and mammalian.
K. Shanmugha Rajan +18 more
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Integrative analysis of a novel snoRNA-based prognostic signature in patients with breast cancer [PDF]
Frontiers in OncologyBackgroundBreast cancer (BC) is the most commonly diagnosed malignancy in women worldwide. Prognostic heterogeneity driven by molecular subtypes and tumor microenvironment underscores the need for novel biomarkers.
Yi Xun +3 more
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Serum small extracellular vesicle–associated snoRNA panel adds diagnostic value to CEA and CYFRA21–1 for non-small cell lung cancer: an exploratory single-center study [PDF]
Frontiers in OncologyBackgroundCirculating small extracellular vesicle (sEV)-associated small nucleolar RNAs (snoRNAs) have emerged as candidate biomarkers because of their stability in biofluids. However, whether these molecular signals provide diagnostic information beyond
Liguang Wang +6 more
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RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing [PDF]
EMBO ReportsSmall nucleolar RNAs (snoRNAs) are a class of eukaryotic non-coding RNA molecules whose precursor transcripts are capped and polyadenylated. However, these end modifications are detrimental to snoRNA function and must be removed, a process typically ...
Valérie Migeot +6 more
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CGSDA: inferring snoRNA-disease associations via ChebNetII and GatedGCN [PDF]
Frontiers in GeneticsIntroductionRecent biomedical studies have highlighted the pivotal role of non-coding RNAs (ncRNAs) in gene regulatory networks, where they influence gene expression, cellular function, and the onset and progression of various diseases.
Yongfu Zou +8 more
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A Novel snoRNA, Gm24418 Attenuates Inflammation Injury After Acute TBI Through Regulating CCL2 [PDF]
Journal of Inflammation ResearchMing Luo,1– 3 Yang Wang,1– 3 Xiaohang Guo,1– 3 Weikang Luo,1– 3 Zhiqiang Yuan,1– 3 Xueping Yang,1– 3 Xudong Fan,1– 3 Zhaoyu Yang,1– 3 Tao Tang1– 3 1Department of Integrated Traditional Chinese and Western Medicine, Institute of Integrative Medicine ...
Luo M +8 more
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Prader-Willi syndrome: reflections on seminal studies and future therapies [PDF]
Open Biology, 2020 Prader-Willi syndrome (PWS) is caused by the loss of function of the paternally inherited 15q11-q13 locus. This region is governed by genomic imprinting, a phenomenon in which genes are expressed exclusively from one parental allele.
Michael S. Chung +3 more
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