Results 21 to 30 of about 15,041 (173)
SnoRNA signatures in cartilage ageing and osteoarthritis [PDF]
Scientific Reports, 2020 Abstract Osteoarthritis presents as a change in the chondrocyte phenotype and an imbalance between anabolic and catabolic processes. Age affects its onset and progression. Small nucleolar RNAs (SnoRNAs) direct chemical modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating changing requirements for ...
Peffers, Mandy J +9 more
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Frontiers in Cardiovascular Medicine, 2022 During spaceflight, astronauts are exposed to various physiological and psychological stressors that have been associated with adverse health effects.
Amit Kumar Rai +15 more
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U8 variants on the brain: a small nucleolar RNA and human disease
RNA Biology, 2022 Small nucleolar RNAs (snoRNAs) are non-coding RNAs vital for ribosomal RNA (rRNA) maturation. The U8 snoRNA, encoded by the SNORD118 gene in humans, is an atypical C/D box snoRNA as it promotes rRNA cleavage rather than 2′–O–methylation and is unique to ...
Emily J. McFadden, Susan J. Baserga
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A Human snoRNA with MicroRNA-Like Functions [PDF]
Molecular Cell, 2008 Small noncoding RNAs function in concert with Argonaute (Ago) proteins to regulate gene expression at the level of transcription, mRNA stability, or translation. Ago proteins bind small RNAs and form the core of silencing complexes. Here, we report the analysis of small RNAs associated with human Ago1 and Ago2 revealed by immunoprecipitation and deep ...
Ender, Christine +8 more
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U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in
BMC Genomics, 2009 Background U3 snoRNA is a box C/D small nucleolar RNA (snoRNA) involved in the processing events that liberate 18S rRNA from the ribosomal RNA precursor (pre-rRNA). Although U3 snoRNA is present in all eukaryotic organisms, most investigations of it have
Charette J Michael, Gray Michael W
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Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation. [PDF]
PLoS ONE, 2013 Box C/D-type small nucleolar RNAs (snoRNAs) are functional RNAs responsible for mediating 2'-O-ribose methylation of ribosomal RNAs (rRNAs) within the nucleolus.
Yuuichi Soeno +13 more
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snoRNAs are Deregulated in Patients with Parkinson’s Disease
Pamukkale Medical Journal, 2022 Purpose: Small nucleolar RNAs are ranging from 65 to 300 nucleotides in length that mediate post-transcriptional RNA modifications. They don’t have a 5′-Cap and a poly-A tail and are categorized as C/D box snoRNAs, H/ACA box snoRNAs, and small Cajal body-specific RNAs. snoRNAs have essential roles in important biological processes such as transcription,
Tokgün, Pervin Elvan +3 more
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Frontiers in Microbiology, 2022 HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay.
Oskar Olsson +15 more
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Genome Biology, 2000 Small RNAs involved in rRNA methylation and ribosome biogenesis have been found in Archaea.
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Matching of Soulmates: Coevolution of snoRNAs and Their Targets [PDF]
Molecular Biology and Evolution, 2013 Ribosomal and small nuclear RNAs (snRNAs) comprise numerous modified nucleotides. The modification patterns are retained during evolution, making it even possible to project them from yeast onto human. The stringent conservation of modification sites and the slow evolution of rRNAs and snRNAs contradicts the rapid evolution of small nucleolar RNA ...
S. Kehr +4 more
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