Results 21 to 30 of about 14,550 (176)
U8 variants on the brain: a small nucleolar RNA and human disease
RNA Biology, 2022 Small nucleolar RNAs (snoRNAs) are non-coding RNAs vital for ribosomal RNA (rRNA) maturation. The U8 snoRNA, encoded by the SNORD118 gene in humans, is an atypical C/D box snoRNA as it promotes rRNA cleavage rather than 2′–O–methylation and is unique to ...
Emily J. McFadden, Susan J. Baserga
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snoRNA U17 Regulates Cellular Cholesterol Trafficking [PDF]
Cell Metabolism, 2015 Cholesterol is required for the growth and viability of mammalian cells and is an obligate precursor for steroid hormone synthesis. Using a loss-of-function screen for mutants with defects in intracellular cholesterol trafficking, a Chinese hamster ovary cell mutant with haploinsufficiency of the U17 snoRNA was isolated.
Jinn, Sarah +11 more
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U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in
BMC Genomics, 2009 Background U3 snoRNA is a box C/D small nucleolar RNA (snoRNA) involved in the processing events that liberate 18S rRNA from the ribosomal RNA precursor (pre-rRNA). Although U3 snoRNA is present in all eukaryotic organisms, most investigations of it have
Charette J Michael, Gray Michael W
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Frontiers in Microbiology, 2022 HIV infection affects the course of tuberculosis (TB), and HIV and Mycobacterium tuberculosis (Mtb) synergize in disease progression through complex immunological interplay.
Oskar Olsson +15 more
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Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation. [PDF]
PLoS ONE, 2013 Box C/D-type small nucleolar RNAs (snoRNAs) are functional RNAs responsible for mediating 2'-O-ribose methylation of ribosomal RNAs (rRNAs) within the nucleolus.
Yuuichi Soeno +13 more
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Genome Biology, 2000 Small RNAs involved in rRNA methylation and ribosome biogenesis have been found in Archaea.
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SnoRNA signatures in cartilage ageing and osteoarthritis [PDF]
Scientific Reports, 2020 Abstract Osteoarthritis presents as a change in the chondrocyte phenotype and an imbalance between anabolic and catabolic processes. Age affects its onset and progression. Small nucleolar RNAs (SnoRNAs) direct chemical modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating changing requirements for ...
Peffers, Mandy J +9 more
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Long Noncoding RNAs with snoRNA Ends [PDF]
Molecular Cell, 2012 We describe the discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (lncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of lncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(
Yin, Qing-Fei +6 more
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Regulation of Alternative Splicing by snoRNAs [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2006 The SNURF-SNRPN locus located on chromosome 15 is maternally imprinted and generates a large transcript containing at least 148 exons. Loss of the paternal allele causes Prader-Willi syndrome (PWS). The 3' end of the transcript harbors several evolutionarily conserved C/D box small nucleolar RNAs (snoRNAs) that are tissue-specifically expressed.
S, Kishore, S, Stamm
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Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies
Non-Coding RNA, 2021 Over recent years, the long known class of small nucleolar RNAs (snoRNAs) have gained interest among the scientific community, especially in the clinical context.
Jaime Calvo Sánchez, Marcel Köhn
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