Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis. [PDF]
J Mol Med (Berl)Lin CY +8 more
europepmc +1 more source
The Drosophila ribonucleoprotein Clueless is required for ribosome biogenesis in vivo. [PDF]
J Biol ChemSen A +3 more
europepmc +1 more source
The RNA-binding protein PRRC2B preserves 5' TOP mRNA during starvation to maintain ribosome biogenesis during nutrient recovery. [PDF]
Nucleic Acids ResGoldberg N +7 more
europepmc +1 more source
A role for the kinetochore protein, NUF2, in ribosome biogenesis. [PDF]
Mol Biol CellBrown TJ +4 more
europepmc +1 more source
The Ribosome Biogenesis—Cancer Connection [PDF]
Cells, 2019 Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the ...
Marianna Penzo +3 more
doaj +6 more sources
Ribosome biogenesis and ribosome therapy in cancer cells [PDF]
Research Results in Pharmacology, 2022 Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj +3 more
doaj +4 more sources
Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins [PDF]
International Journal of Molecular Sciences, 2021 Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis. Mitochondrial ribosomes (mitoribosomes) perform translation of the proteins essential for the oxidative phosphorylation system. The biogenesis of cytoribosomes and
Giulia Russo, Annapina Russo
exaly +4 more sources
Ribosome biogenesis in disease: new players and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao +7 more
doaj +2 more sources
Inhibiting eukaryotic ribosome biogenesis [PDF]
BMC Biology, 2019 Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential.
Dominik Awad +9 more
doaj +3 more sources