Results 1 to 10 of about 144,255 (280)

The Ribosome Biogenesis—Cancer Connection [PDF]

Cells, 2019
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the ...
Lorenzo Montanaro, Marianna Penzo, Davide Trerè   +2 more
exaly   +8 more sources

Autonomous ribosome biogenesis in vitro [PDF]

Nature Communications
Ribosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Yuishin Kosaka, Yumi Miyawaki, Megumi Mori, Shunsuke Aburaya, Chisato Nishizawa, Takeshi Chujo, Tatsuya Niwa, Takumi Miyazaki, Takashi Sugita, Mao Fukuyama, Hideki Taguchi, Kazuhito Tomizawa, Kenji Sugase, Mitsuyoshi Ueda, Wataru Aoki   +14 more
doaj   +5 more sources

Ribosome biogenesis and ribosome therapy in cancer cells [PDF]

Research Results in Pharmacology, 2022
Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj, Rifat Hadziselimovic, Hilada Nefic, Nexhibe Nuhii   +3 more
doaj   +6 more sources

Ribosome biogenesis in osteoarthritis: mechanisms and therapeutic potential [PDF]

Journal of Translational Medicine
Background Ribosomes are the core machinery for cellular protein synthesis, and defects in their biogenesis have been confirmed to be closely associated with various diseases.
Zewen Xu, Zhiwei Pei, Haobo Yang, Shanjie Guo, Qiang Li, Liuchang Jiang, Jing Wang, Leipeng Wang, Dexin Liu, Xuanyin Chen, Baoxin Zhang, Ting Hao   +11 more
doaj   +2 more sources

G-patch proteins: important regulators of pre-mRNA splicing and ribosome biogenesis [PDF]

Frontiers in Cell and Developmental Biology
Pre-mRNA splicing is a fundamental step in eukaryotic gene expression, carried out by the spliceosome. This large and dynamic ribonucleoprotein complex undergoes extensive structural rearrangements during each splicing event.
Laura Olivia Karika, Ingrid Cipakova, Lucia Hronska, Lubos Cipak   +3 more
doaj   +2 more sources

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

Cell Reports, 2018
Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain ...
Yulia V Surovtseva, Lisa M Ogawa, Katherine I Farley-Barnes   +2 more
exaly   +3 more sources

FOSL1 promotes homologous recombination repair and camptothecin resistance via TCOF1-mediated ribosome biogenesis in non-small cell lung cancer [PDF]

Translational Oncology
Background: Camptothecin (CPT) and its derivatives are important chemotherapeutic agents; however, intrinsic and acquired tolerance frequently limits their long-term efficacy.
Chunmei Hao, Luojun Chen, Fuben Liao, Lulu Chen, Yi Yao, Qibin Song   +5 more
doaj   +2 more sources

Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans.

PLoS Biology, 2023
Interorgan communication is crucial for multicellular organismal growth, development, and homeostasis. Cell nonautonomous inhibitory cues, which limit tissue-specific growth alterations, are not well characterized due to cell ablation approach ...
Qiuxia Zhao, Rekha Rangan, Shinuo Weng, Cem Özdemir, Elif Sarinay Cenik   +4 more
doaj   +1 more source

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Nature Communications, 2023
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller   +14 more
doaj   +1 more source

Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications

Biomedicines, 2022
Ribosome biogenesis is a cellular process critical for protein homeostasis during cell growth and multiplication. Our previous study confirmed up-regulation of ribosome biogenesis during endometriosis progression and malignant transition, thus anti ...
Cherry Yin-Yi Chang, An-Jen Chiang, Man-Ju Yan, Ming-Tsung Lai, Yun-Yi Su, Hsin-Yi Huang, Chan-Yu Chang, Ya-Hui Li, Pei-Fen Li, Chih-Mei Chen, Tritium Hwang, Chloe Hogg, Erin Greaves, Jim Jinn-Chyuan Sheu   +13 more
doaj   +1 more source