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The Ribosome Biogenesis—Cancer Connection [PDF]
Cells, 2019 Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the ...
Marianna Penzo +2 more
exaly +8 more sources
Autonomous ribosome biogenesis in vitro [PDF]
Nature CommunicationsRibosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors.
Yuishin Kosaka +14 more
doaj +6 more sources
Ribosome biogenesis and ribosome therapy in cancer cells [PDF]
Research Results in Pharmacology, 2022 Introduction: The process of protein synthesis is a vital process for all kingdoms of life. The ribosome is a ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and to tightly regulate and ensure cells ...
Gazmend Temaj +3 more
doaj +5 more sources
Ribosome Biogenesis in Archaea [PDF]
Frontiers in Microbiology, 2021 Making ribosomes is a major cellular process essential for the maintenance of functional ribosome homeostasis and to ensure appropriate gene expression.
Paola Londei, Sébastien Ferreira-Cerca
doaj +7 more sources
Ribosome Biogenesis Alterations in Colorectal Cancer [PDF]
Cells, 2020 Many studies have focused on understanding the regulation and functions of aberrant protein synthesis in colorectal cancer (CRC), leaving the ribosome, its main effector, relatively underappreciated in CRC.
Sophie Nait Slimane +7 more
doaj +5 more sources
RNase III, Ribosome Biogenesis and Beyond [PDF]
Microorganisms, 2021 The ribosome is the universal catalyst for protein synthesis. Despite extensive studies, the diversity of structures and functions of this ribonucleoprotein is yet to be fully understood.
Maxence Lejars +2 more
doaj +4 more sources
Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins [PDF]
International Journal of Molecular Sciences, 2021 Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis. Mitochondrial ribosomes (mitoribosomes) perform translation of the proteins essential for the oxidative phosphorylation system. The biogenesis of cytoribosomes and
, Annapina Russo, Pecoraro Annalisa
exaly +4 more sources
Inhibiting eukaryotic ribosome biogenesis [PDF]
BMC Biology, 2019 Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential.
Dominik Awad +9 more
doaj +3 more sources
Eukaryotic ribosome biogenesis at a glance [PDF]
Journal of Cell Science, 2013 Summary Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic cells, ribosome biogenesis requires the coordinated activity of all three RNA polymerases and the orchestrated work of many (>200 ...
Thomson, Emma +2 more
openaire +4 more sources
Ribosome biogenesis in disease: new players and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao +7 more
doaj +2 more sources