Results 41 to 50 of about 144,255 (280)
The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14 [PDF]
, 2005 One of the proteins identified as being involved in ribosome biogenesis by high-throughput studies, a putative P-loop-type kinase termed Fap7 (YDL166c), was shown to be required for the conversion of 20S pre-rRNA to 18S rRNA.
Nandineni, Madhusudan R +2 more
core +1 more source
Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits [PDF]
, 2003 Cic1p/Nsa3p was previously reported to be associated with the 26S proteasome and required for the degradation of specific substrates, but was also shown to be associated with early pre-60S particles and to be localized to the nucleolus.
Tollervey, D +7 more
core +1 more source
Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion [PDF]
, 2023 Cancer cells are especially sensitive to perturbations in ribosome biogenesis as they rely on finely tuned protein homeostasis to facilitate their rapid growth and proliferation.
Zhang, Yinfeng +13 more
core +1 more source
Ribosome biogenesis: A central player in liver diseases
Genes and DiseasesRibosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo +3 more
doaj +1 more source
PLoS ONE, 2017 Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification.
Virginie Marcel +11 more
doaj +1 more source
Ribosome biogenesis: Stripping for AAAction? [PDF]
Current Biology, 2001 Ribosomal subunits are assembled in the nucleolus before being transported to the cytoplasm. Recent work has identified both a protein that may play a key role in restructuring the large, 60S subunit prior to transport and factors that facilitate transport itself.
openaire +3 more sources
mBio, 2023 Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins.
Maikke B. Ohlson +8 more
doaj +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
Increasing Complexity of Ribosomes and Their Biogenesis
International Journal of Molecular Sciences, 2022 According to the classic ribosome model, developed in the 1960s and 1970s, its only function is to translate the four-letter nucleic acid code into the 20 amino acid peptide-code, while polymerizing amino acids into peptides with the help of a large complement of tRNAs and translation factors that cycle on and off the ribosome [...]
openaire +2 more sources
BMC Plant Biology, 2023 Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek +5 more
doaj +1 more source