Results 41 to 50 of about 57,712 (282)

Ribosome biogenesis: Stripping for AAAction? [PDF]

Current Biology, 2001
Ribosomal subunits are assembled in the nucleolus before being transported to the cytoplasm. Recent work has identified both a protein that may play a key role in restructuring the large, 60S subunit prior to transport and factors that facilitate transport itself.
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40S ribosome biogenesis co-factors are essential for gametophyte and embryo development

, 2013
Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Roman Martin, Martin, Roman, Roman Martin (85483), Simm, Stefan, Markus T. Bohnsack, Markus T Bohnsack, Benjamin L. Weis (277837), Stefan Simm, Sandra Missbach (277836), Markus T. Bohnsack (277840), Benjamin L Weis, Enrico Schleiff, Weis, Benjamin L., Sandra Missbach, Bohnsack, Markus, Mißbach, Sandra, Stefan Simm (277838), Schleiff, Enrico, Enrico Schleiff (49377), Lafontaine, Denis, Bohnsack, Markus T., Ra Missbach, Benjamin L. Weis   +22 more
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Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits [PDF]

, 2003
Cic1p/Nsa3p was previously reported to be associated with the 26S proteasome and required for the degradation of specific substrates, but was also shown to be associated with early pre-60S particles and to be localized to the nucleolus.
Tollervey, D, D. Tollervey, Oeffinger, M, Bozzoni, I, M. Oeffinger, Fatica, A, BOZZONI, Irene, FATICA, Alessandro   +7 more
core   +1 more source

Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication

mBio, 2023
Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins.
Maikke B. Ohlson, Jennifer L. Eitson, Alexandra I. Wells, Ashwani Kumar, Seoyeon Jang, Chunyang Ni, Chao Xing, Michael Buszczak, John W. Schoggins   +8 more
doaj   +1 more source

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis

BMC Plant Biology, 2023
Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek, Anna Golisz-Mocydlarz, Michal Krzyszton, Justyna Piotrowska, Malgorzata Lichocka, Joanna Kufel   +5 more
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Increasing Complexity of Ribosomes and Their Biogenesis

International Journal of Molecular Sciences, 2022
According to the classic ribosome model, developed in the 1960s and 1970s, its only function is to translate the four-letter nucleic acid code into the 20 amino acid peptide-code, while polymerizing amino acids into peptides with the help of a large complement of tRNAs and translation factors that cycle on and off the ribosome [...]
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Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Frontiers in Oncology, 2021
Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.
Lanjuan Mi, Qinghui Qi, Haowen Ran, Lishu Chen, Da Li, Dake Xiao, Jiaqi Wu, Yan Cai, Songyang Zhang, Yuanyuan Li, Bohan Li, Jiong Xie, Haohao Huang, Tao Li, Tao Zhou, Ailing Li, Ji Qi, Fangye Li, Jianghong Man   +18 more
doaj   +1 more source

The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

, 2008
Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis.
Wöhnert, Jens, Hart, P. John, Meyer, Britta, Entian, Karl-Dieter, Schirf, Virgil, Kötter, Peter, Taylor, Alexander B., Demeler, Borries, Leal, Belinda Z.   +8 more
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Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq

BMC Genomics, 2023
The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis. Recent studies have suggested that it also plays an important role in organizing chromatin architecture.
Trevor F. Freeman, Qiuxia Zhao, Agustian Surya, Reed Rothe, Elif Sarinay Cenik   +4 more
doaj   +1 more source

When ribosomes go bad: diseases of ribosome biogenesis [PDF]

Molecular BioSystems, 2010
Abstract Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered.
Emily F, Freed, Franziska, Bleichert, Laura M, Dutca, Susan J, Baserga   +3 more
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