Results 41 to 50 of about 87,402 (287)

Ribosomal DNA-connecting ribosome biogenesis and chromosome biology [PDF]

open access: yesChromosome Research, 2019
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome.
Lev, Porokhovnik, Jennifer L, Gerton
openaire   +2 more sources

Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways

open access: yesOpen Biology, 2022
Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of function in the translation machinery components results in
Agustian Surya, Elif Sarinay-Cenik
doaj   +1 more source

Cotranslational folding of proteins on the ribosome.

open access: yes, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

open access: yesCell Reports, 2015
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process.
Lukas Badertscher   +12 more
doaj   +1 more source

Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" [PDF]

open access: yes, 2013
The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown.
Entian, Karl-Dieter   +3 more
core   +1 more source

Rustless translation [PDF]

open access: yes, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Karl-Peter Hopfner, Roy
core   +1 more source

Genetic landscape of autism spectrum disorder in Vietnamese children [PDF]

open access: yes, 2020
Autism spectrum disorder (ASD) is a complex disorder with an unclear aetiology and an estimated global prevalence of 1%. However, studies of ASD in the Vietnamese population are limited.
Bui, HTP   +12 more
core   +2 more sources

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation [PDF]

open access: yes, 2017
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin.
Begley, Victoria Sarah   +11 more
core   +3 more sources

Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients.

open access: yesPLoS ONE, 2017
Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification.
Virginie Marcel   +11 more
doaj   +1 more source

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