Results 41 to 50 of about 142,894 (282)
Small Molecule RBI2 Disrupts Ribosome Biogenesis through Pre-rRNA Depletion [PDF]
, 2023 Cancer cells are especially sensitive to perturbations in ribosome biogenesis as they rely on finely tuned protein homeostasis to facilitate their rapid growth and proliferation.
Zhang, Yinfeng +13 more
core +1 more source
Ribosome biogenesis: A central player in liver diseases
Genes and DiseasesRibosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo +3 more
doaj +1 more source
BMC Plant Biology, 2023 Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek +5 more
doaj +1 more source
PLoS ONE, 2017 Acute myeloid leukemia (AML) is a heterogeneous disease. Prognosis is mainly influenced by patient age at diagnosis and cytogenetic alterations, two of the main factors currently used in AML patient risk stratification.
Virginie Marcel +11 more
doaj +1 more source
Ribosome biogenesis: Stripping for AAAction? [PDF]
Current Biology, 2001 Ribosomal subunits are assembled in the nucleolus before being transported to the cytoplasm. Recent work has identified both a protein that may play a key role in restructuring the large, 60S subunit prior to transport and factors that facilitate transport itself.
openaire +3 more sources
Frontiers in Oncology, 2021 Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.
Lanjuan Mi +18 more
doaj +1 more source
Increasing Complexity of Ribosomes and Their Biogenesis
International Journal of Molecular Sciences, 2022 According to the classic ribosome model, developed in the 1960s and 1970s, its only function is to translate the four-letter nucleic acid code into the 20 amino acid peptide-code, while polymerizing amino acids into peptides with the help of a large complement of tRNAs and translation factors that cycle on and off the ribosome [...]
openaire +2 more sources
BMC Genomics, 2023 The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis. Recent studies have suggested that it also plays an important role in organizing chromatin architecture.
Trevor F. Freeman +4 more
doaj +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source