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Nature Communications, 2023 Here the authors developed a nucleolus Hi-C technique (nHi-C) for enriching nucleolus-associated interactions, and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells at high resolution.
Yingping Hou, Haowei Meng, Cheng Li
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Cell Reports, 2016 The nucleolus is the site of rRNA gene transcription, rRNA processing, and ribosome biogenesis. However, the nucleolus also plays additional roles in the cell. We isolated nucleoli using fluorescence-activated cell sorting (FACS) and identified nucleolus-
Craig Pikaard +2 more
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Therapeutic Approaches Targeting Nucleolus in Cancer
Cells, 2019 The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in ...
Pietro Carotenuto, Annapina Russo
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Mètode Science Studies Journal: Annual Review, 2021 Space exploration will require life support systems, in which plants can provide nutrients, oxygen, moisture, and psychological well-being and eliminate wastes. In alien environments, plants must adapt to a different gravity force, even the zero gravity
F. Javier Medina
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iScience, 2022 Summary: Discovering the adaptation mechanisms of plants to the space environment is essential for supporting human space exploration. Transcriptomic analyses allow the identification of adaptation response pathways by detecting changes in gene ...
Aránzazu Manzano +3 more
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Cells, 2021 Due to their exceptional simplicity of organization, viruses rely on the resources, molecular mechanisms, macromolecular complexes, regulatory pathways, and functional compartments of the host cell for an effective infection process.
Olga V. Iarovaia +3 more
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Fibrillarin-GFP Facilitates the Identification of Meiotic Competent Oocytes
Frontiers in Cell and Developmental Biology, 2021 The nucleolus undergoes significant functional changes and plays important roles during mammalian oocyte meiotic maturation. Fibrillarin (FBL) is the component of nucleolar small nuclear ribonucleoprotein (snRNP) particle and localizes to the dense ...
Ting Wang, Ting Wang, Jie Na
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Beyond ribosome biogenesis: noncoding nucleolar RNAs in physiology and tumor biology
Nucleus, 2023 The nucleolus, the largest subcompartment of the nucleus, stands out from the nucleoplasm due to its exceptionally high local RNA and low DNA concentrations.
Nuray Böğürcü-Seidel +3 more
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The structure of the mitotic spindle and nucleolus during mitosis in the amebo-flagellate Naegleria. [PDF]
PLoS ONE, 2012 Mitosis in the amebo-flagellate Naegleria pringsheimi is acentrosomal and closed (the nuclear membrane does not break down). The large central nucleolus, which occupies about 20% of the nuclear volume, persists throughout the cell cycle.
Charles J Walsh
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iScience, 2020 Summary: The enlarged distinct bulky-ball-like nucleolus matrix assembly is observed in most cancer stem cells (CSCs); however, the underlying mechanism is largely unknown.
Wei-Hsuan Yu +8 more
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