Results 31 to 40 of about 62,842 (285)
Therapeutic Approaches Targeting Nucleolus in Cancer
Cells, 2019 The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in ...
Pietro Carotenuto +4 more
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On the nucleolus of neighbor games [PDF]
European Journal of Operational Research, 2003 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Herbert Hamers +4 more
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Viral Impact in Autoimmune Diseases: Expanding the “X Chromosome–Nucleolus Nexus” Hypothesis
Frontiers in Immunology, 2017 Viruses are suspected of significant roles in autoimmune diseases but the mechanisms are unclear. We get some insight by considering demands a virus places on host cells. Viruses not only require production of their own proteins, RNA and/or DNA, but also
Wesley H. Brooks
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A Wiring of the Human Nucleolus [PDF]
Molecular Cell, 2006 Recent proteomic efforts have created an extensive inventory of the human nucleolar proteome. However, approximately 30% of the identified proteins lack functional annotation. We present an approach of assigning function to uncharacterized nucleolar proteins by data integration coupled to a machine-learning method.
Hinsby, Anders M. +8 more
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Nature Communications, 2023 Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi +15 more
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What is new in the nucleolus? [PDF]
The EMBO Reports, 2006 This EMBO Workshop on the Nucleolus: New Perspectives took place between 27 and 29 March 2006, in York, UK, and was organized by J. Wainwright, C. Rubbi, J. Milner and J. Hiscox. ![][1] York, UK, was a good choice for the venue of this workshop because the history of nucleolar research—like the city—falls into distinct eras. Founded by the Romans in
Matthews, David A, Olson, Mark O.J
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Genome Organization in and around the Nucleolus
Cells, 2019 The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal RNA (rRNA) genes.
Cristiana Bersaglieri, Raffaella Santoro
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PLoS Pathogens, 2010 The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus--a feature exclusive to this pathogen group. Here, using a combination
Paul Dean +5 more
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Cross-compartment signal propagation in the mitotic exit network
eLife, 2021 In budding yeast, the mitotic exit network (MEN), a GTPase signaling cascade, integrates spatial and temporal cues to promote exit from mitosis. This signal integration requires transmission of a signal generated on the cytoplasmic face of spindle pole ...
Xiaoxue Zhou +3 more
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The plurifunctional nucleolus [PDF]
Nucleic Acids Research, 1998 The nucleolus of eukaryotic cells was first described in the early 19th century and was discovered in the 1960s to be the seat of ribosome synthesis. Although rRNA transcription, rRNA processing and ribosome assembly have been clearly established as major functions of the nucleolus, recent studies suggest that the nucleolus participates in many other ...
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