Results 31 to 40 of about 51,957 (163)
Cross-compartment signal propagation in the mitotic exit network
eLife, 2021 In budding yeast, the mitotic exit network (MEN), a GTPase signaling cascade, integrates spatial and temporal cues to promote exit from mitosis. This signal integration requires transmission of a signal generated on the cytoplasmic face of spindle pole ...
Xiaoxue Zhou +3 more
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Nucleolus in the Spotlight [PDF]
Cell Cycle, 2004 The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of
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PLoS Pathogens, 2022 Nucleoli are membrane-less structures located within the nucleus and are known to be involved in many cellular functions, including stress response and cell cycle regulation. Besides, many viruses can employ the nucleolus or nucleolar proteins to promote
Sereina O Sutter +8 more
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The Unknown within the Known: Nucleolus, Understudied Compartment in the Filamentous Fungi
MycobiologyNucleolus is the most conspicuous sub-nuclear compartment that is well known as the site of RNA polymerase I-mediated rDNA transcription and assembly of ribosome subunits in eukaryotes.
Song Hee Lee, Namo Dubey, Junhyun Jeon
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PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions
Nature Communications, 2023 The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stress.
Xiaocen Jin +10 more
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The plurifunctional nucleolus [PDF]
Nucleic Acids Research, 1998 The nucleolus of eukaryotic cells was first described in the early 19th century and was discovered in the 1960s to be the seat of ribosome synthesis. Although rRNA transcription, rRNA processing and ribosome assembly have been clearly established as major functions of the nucleolus, recent studies suggest that the nucleolus participates in many other ...
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A Wiring of the Human Nucleolus [PDF]
Molecular Cell, 2006 Recent proteomic efforts have created an extensive inventory of the human nucleolar proteome. However, approximately 30% of the identified proteins lack functional annotation. We present an approach of assigning function to uncharacterized nucleolar proteins by data integration coupled to a machine-learning method.
Hinsby, Anders M. +8 more
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Nature Communications, 2018 The nucleolus is a membrane-less organelle and both Nucleophosmin (NPM1) and Surfeit locus protein 6 (SURF6) are abundant proteins within the nucleolus. Here the authors employ biophysical methods to study the properties of NPM1-S6N droplets and provide ...
Mylene C. Ferrolino +3 more
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The nucleolus is the site for inflammatory RNA decay during infection
Nature Communications, 2022 The nucleolus is the traditional site for ribosomal RNA biogenesis. Here, the authors find that the nucleolus is a site of inflammatory pre-mRNA turnover and elucidated how immune homeostasis can be maintained by controlling inflammatory gene expression.
Taeyun A. Lee +18 more
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