Results 41 to 50 of about 87,414 (290)
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +2 more sources
PLoS Pathogens, 2010 The nucleolus is a multifunctional structure within the nucleus of eukaryotic cells and is the primary site of ribosome biogenesis. Almost all viruses target and disrupt the nucleolus--a feature exclusive to this pathogen group. Here, using a combination
Paul Dean +5 more
doaj +1 more source
Cross-compartment signal propagation in the mitotic exit network
eLife, 2021 In budding yeast, the mitotic exit network (MEN), a GTPase signaling cascade, integrates spatial and temporal cues to promote exit from mitosis. This signal integration requires transmission of a signal generated on the cytoplasmic face of spindle pole ...
Xiaoxue Zhou +3 more
doaj +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
PLoS Pathogens, 2022 Nucleoli are membrane-less structures located within the nucleus and are known to be involved in many cellular functions, including stress response and cell cycle regulation. Besides, many viruses can employ the nucleolus or nucleolar proteins to promote
Sereina O Sutter +8 more
doaj +1 more source
The Unknown within the Known: Nucleolus, Understudied Compartment in the Filamentous Fungi
MycobiologyNucleolus is the most conspicuous sub-nuclear compartment that is well known as the site of RNA polymerase I-mediated rDNA transcription and assembly of ribosome subunits in eukaryotes.
Song Hee Lee, Namo Dubey, Junhyun Jeon
doaj +1 more source
PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions
Nature Communications, 2023 The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stress.
Xiaocen Jin +10 more
doaj +1 more source
AKT regulates NPM dependent ARF localization and p53mut stability in tumors [PDF]
, 2014 Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive.
Abraham, Aswin G. +12 more
core +2 more sources
Ready for the design of voting rules? [PDF]
, 2014 The design of fair voting rules has been addressed quite often in the literature. Still, the so-called inverse problem is not entirely resolved. We summarize some achievements in this direction and formulate explicit open questions and conjectures ...
Kurz, Sascha
core +1 more source
Angewandte Chemie, EarlyView.Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo +3 more
wiley +2 more sources