DNA replication stress restricts ribosomal DNA copy number. [PDF]
PLoS Genetics, 2017 Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus.
Devika Salim +6 more
doaj +1 more source
SMN-deficient cells exhibit increased ribosomal DNA damage
Life Science Alliance, 2022 SMN deficiency leads to elevated ribosomal DNA damage that results in impaired ribosomal RNA synthesis and translation and is accompanied by a motor neuron-specific down-regulation of DDX21 protein.
Evangelia Karyka +13 more
doaj +1 more source
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Nature Communications, 2020 DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar ...
Clémence Mooser +15 more
doaj +1 more source
DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome
Frontiers in Genetics, 2022 Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21, and 22, trisomy of chromosome 21 confers an excess of rDNA copies to ...
Francesco Ravaioli +26 more
doaj +1 more source
Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase
BMC Cell Biology, 2003 Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The
Paric Enesa +2 more
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Recognition of Ribosomal RNA Sites in DNA, I. Analysis of the E. coli System [PDF]
, 1965 The evidence recently presented of specific hybridization between bacterial ribosomal RNA and homologous DNA1-3 has indicated the possibility of a biochemical approach to the problem of the identification of ribosomal RNA sites in DNA.
Attardi, Giuseppe +2 more
core +1 more source
Early life stress inhibits expression of ribosomal RNA in the developing hippocampus. [PDF]
PLoS ONE, 2014 Children that are exposed to abuse or neglect show abnormal hippocampal function. However, the developmental mechanisms by which early life stress (ELS) impairs normal hippocampal development have not been elucidated. Here we propose that exposure to ELS
Lan Wei, Jin Hao, Arie Kaffman
doaj +1 more source
Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. [PDF]
, 2001 A HUVEC cDNA library was screened with sera from two patients who had developed transplant-associated coronary artery disease (TxCAD) following cardiac transplantation.
Linke, A.T. +5 more
core +4 more sources
Memorias do Instituto Oswaldo Cruz, 2004 A ribosome association factor (AF) was isolated from the yeast Sacchharomyces cerevisiae. Partial amino acid sequence of AF was determined from its fragment of 25 kDa isolated by treating AF with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-Bromoindolenine ...
Heriberto Correia +5 more
doaj +1 more source
Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae [PDF]
, 2003 We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened lifespan of dna2 mutants. Now we use the ribosomal DNA locus,
Budd, Martin +3 more
core +2 more sources