Results 1 to 10 of about 2,174,246 (295)

Mild cognitive impairment is associated with low copy number of ribosomal genes in the genomes of elderly people [PDF]

Frontiers in Genetics, 2022
Introduction: Mild cognitive impairments (MCI) accompanying aging are associated with oxidative stress. The ability of cells to respond to stress is determined by the protein synthesis level, which depends on the ribosomes number.
Natalia N. Veiko, Elizaveta S. Ershova, Elizaveta S. Ershova, Roman V. Veiko, Pavel E. Umriukhin, Pavel E. Umriukhin, Pavel E. Umriukhin, Marat V. Kurmyshev, Georg P. Kostyuk, Sergey I. Kutsev, Svetlana V. Kostyuk, Svetlana V. Kostyuk   +11 more
doaj   +2 more sources

Many ribosomal protein genes are cancer genes in zebrafish. [PDF]

PLoS Biology, 2004
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or
Adam Amsterdam, Kirsten C Sadler, Kevin Lai, Sarah Farrington, Roderick T Bronson, Jacqueline A Lees, Nancy Hopkins   +6 more
doaj   +4 more sources

Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group [PDF]

Frontiers in Genetics, 2018
Introduction: The multi-copied genes coding for the human 18, 5.8, and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA.
Elena M. Malinovskaya, Elizaveta S. Ershova, Vera E. Golimbet, Lev N. Porokhovnik, Nataliya A. Lyapunova, Serguey I. Kutsev, Natalia N. Veiko, Svetlana V. Kostyuk   +7 more
doaj   +2 more sources

Intron dynamics in ribosomal protein genes. [PDF]

PLoS ONE, 2007
The role of spliceosomal introns in eukaryotic genomes remains obscure. A large scale analysis of intron presence/absence patterns in many gene families and species is a necessary step to clarify the role of these introns.
Maki Yoshihama, Hung D Nguyen, Naoya Kenmochi   +2 more
doaj   +4 more sources

Human rDNA and Cancer

Cells, 2021
In human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles ...
Evgeny Smirnov, Nikola Chmúrčiaková, Dušan Cmarko   +2 more
doaj   +1 more source

Evidence for further non-coding RNA genes in the fungal rDNA region [PDF]

MycoKeys, 2022
Non-coding RNA (ncRNA) genes play important, but incompletely understood, roles in various cellular processes, notably translation and gene regulation.
Magnus Alm Rosenblad, Ellen Larsson, Arttapon Walker, Naritsada Thongklang, Christian Wurzbacher, R. Henrik Nilsson   +5 more
doaj   +3 more sources

Involvement of Target of Rapamycin (TOR) Signaling in the Regulation of Crosstalk between Ribosomal Protein Small Subunit 6 Kinase-1 (RPS6K-1) and Ribosomal Proteins

Plants, 2023
The target of rapamycin (TOR) protein phosphorylates its downstream effector p70kDa ribosomal protein S6 kinases (S6K1) for ribosome biogenesis and translation initiation in eukaryotes.
Achala Bakshi, Mazahar Moin, Meher B. Gayatri, Aramati B. M. Reddy, Raju Datla, Maganti S. Madhav, Pulugurtha B. Kirti   +6 more
doaj   +1 more source

КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ АЛЛЕРГИЧЕСКОГО РИНИТА И ИХ ВЗАИМОСВЯЗЬ С АКТИВНОСТЬЮ БЕЛОКСИНТЕЗИРУЮЩЕГО АППАРАТА КЛЕТКИ

Архивъ внутренней медицины, 2012
This article describes clinical and cytogenetic peculiarities of children’s allergic rhinitis. The dates of changes of the functional activity of ribosomal genes at children’s allergic rhinitis are received.
Н. В. Стабровская, В. П. Иванов, Е. В. Трубникова, А. Д. Богомазов, А. А. Дедков, Е. Л. Полякова   +5 more
doaj   +1 more source

Using ribosomal protein genes as reference: a tale of caution. [PDF]

PLoS ONE, 2008
BACKGROUND: Housekeeping genes are needed in every tissue as their expression is required for survival, integrity or duplication of every cell. Housekeeping genes commonly have been used as reference genes to normalize gene expression data, the ...
Lieven Thorrez, Katrijn Van Deun, Léon-Charles Tranchevent, Leentje Van Lommel, Kristof Engelen, Kathleen Marchal, Yves Moreau, Iven Van Mechelen, Frans Schuit   +8 more
doaj   +1 more source

Phylogenetic study of Aliinostoc species (Cyanobacteria) using pc-igs, nifH and mcy as markers for investigation of horizontal gene transfer

Acta Biologica Slovenica, 2022
Selection of genes that have not been horizontally transferred for prokaryote phylogenetic studies is regarded as a challenging task. Internal transcribed spacer of ribosomal genes (16S–23S ITS), microcystin synthetase genes (mcy), nitrogenase (nifH) and
Bahareh Nowruzi
doaj   +1 more source