Results 1 to 10 of about 2,892,023 (342)
DNA replication stress restricts ribosomal DNA copy number. [PDF]
PLoS Genetics, 2017 Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus.
Devika Salim +6 more
doaj +6 more sources
DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription* [PDF]
Journal of Biological Chemistry, 2013 Background: Transcription initiation by RNA polymerase I requires protein-protein interactions between Rrn3, polymerase, and core factors. Results: Mutagenesis of a putative DNA binding domain in Rrn3 had no effect on essential protein-protein ...
Ann N. Stepanchick +5 more
semanticscholar +3 more sources
Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus [PDF]
Epigenetics, 2023 The human ribosomal DNA (rDNA) copy number (CN) has been challenging to analyse, and its sequence has been excluded from reference genomes due to its highly repetitive nature. The 45S rDNA locus encodes essential components of the cell, nevertheless rDNA
Aleem Razzaq +4 more
doaj +2 more sources
16S ribosomal DNA amplification for phylogenetic study
Journal of Bacteriology, 1991 A set of oligonucleotide primers capable of initiating enzymatic amplification (polymerase chain reaction) on a phylogenetically and taxonomically wide range of bacteria is described along with methods for their use and examples. One pair of primers is capable of amplifying nearly full-length 16S ribosomal DNA (rDNA) from many bacterial genera; the ...
W. Weisburg +3 more
semanticscholar +4 more sources
Genome-wide DNA methylation profiles and ribosomal DNA copy number at birth [PDF]
EpigeneticsRibosomal DNA copy number (rDNAcn) and DNA methylation are important modulators of the human genome, both studied in relation to overall cellular function, biological ageing, and disease development.
Kathrin Barth +5 more
doaj +2 more sources
RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability [PDF]
RNA BiologyTranscription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand +7 more
doaj +2 more sources
CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci [PDF]
BiomedicinesWhile genotoxic chemotherapeutic agents are among the most effective tools to combat cancer, they are often associated with severe adverse effects caused by indiscriminate DNA damage in non-tumor tissue as well as increased risk of secondary ...
Donald P. Cameron +8 more
doaj +2 more sources
Neurodegeneration-associated instability of ribosomal DNA.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Homologous recombination (HR)-mediated instability of the repetitively organized ribosomal DNA (rDNA) has been proposed as a mediator of cell senescence in yeast triggering the DNA damage response. High individual variability in the content of human rDNA suggests that this genomic region remained relatively unstable throughout evolution.
Justin Hallgren +4 more
semanticscholar +3 more sources
Isolation and study of morphology and phylogeny of arbuscular mycorrhizal fungi coexisting with the roots of some medicinal plants in Kerman province [PDF]
مجله بیوتکنولوژی کشاورزی, 2020 Objective Plants that have a symbiotic relationship with arbuscular mycorrhizal fungi (AMF) compared with non-mycorrhizal plants have a higher ability to resist against various biotic and abiotic environmental stresses such as drought, salinity, pests ...
Eidi bazgir +3 more
doaj +1 more source
Guangdong nongye kexue, 2022 【Objective】The study was carried out to explore the molecular identification of Wuzhi No. 2 (original name: Zizhi S2), a new cultivar of Ganoderma sp., by rDNA-ITS sequence analysis and ITS2 secondary structure model.【Method】The sequences of Wuzhi No.
Liyi ZHONG +3 more
doaj +1 more source