Results 11 to 20 of about 2,892,023 (342)

Engineering the ribosomal DNA in a megabase synthetic chromosome

Science, 2017
INTRODUCTION It has long been an interesting question whether a living cell can be constructed from scratch in the lab, a goal that may not be realized anytime soon. Nonetheless, with advances in DNA synthesis technology, the complete genetic material of
Wei-Meng Zhang, Guanghou Zhao, Zhouqing Luo, Yicong Lin, Lihui Wang, Yakun Guo, Ann Wang, Shuangying Jiang, Qingwen Jiang, Jianhui Gong, Yun Wang, S. Hou, Jing Huang, Tianyi Li, Y. Qin, Junkai Dong, Qin Qin, Jiaying Zhang, Xinzhi Zou, Xi He, Li Zhao, Yibo Xiao, Meng Xu, E. Cheng, Ning Huang, Tong Zhou, Yue Shen, Roy S. K. Walker, Yisha Luo, Zheng Kuang, L. Mitchell, Kun Yang, S. Richardson, Yi Wu, Bing-Zhi Li, Yingjin Yuan, Huanming Yang, Jiwei Lin, Guoqiang Chen, Qingyu Wu, J. Bader, Yizhi Cai, J. Boeke, Junbiao Dai   +43 more
semanticscholar   +3 more sources

The retrotransposon R2 maintains Drosophila ribosomal DNA repeats

bioRxiv, 2021
Ribosomal DNA (rDNA) loci contain the hundreds of tandemly repeated copies of ribosomal RNA genes needed to support cellular viability. This repetitiveness makes it highly susceptible to copy number (CN) loss, threatening multi-generational maintenance ...
Jonathan O. Nelson, Alyssa Slicko, Y. Yamashita   +2 more
semanticscholar   +1 more source

Characterization of Yeast Ribosomal DNA [PDF]

European Journal of Biochemistry, 1975
High‐molecular‐weight yeast ribosomal DNA, purified by preparative Hg2/Cs2SO4 gradient centrifugation, was characterized using RNA‐DNA hybridization, CsCl gradient analysis and denaturation‐renaturation experiments. The following conclusions are drawn from the results of these studies.
J, Retèl, H, Van Keulen
openaire   +2 more sources

Evaluation of the complete nuclear rDNA unit sequence of the jellyfish Cyanea nozakii Kishinouye (Scyphozoa: Semaeostomeae) for molecular discrimination

Animal Cells and Systems, 2021
The harmful jellyfish Cyanea nozakii Kishinouye has frequently occurred on Korean coasts, and its blooms have caused serious ecological and economic damages. DNA sequences of the C. nozakii for molecular detection and discrimination are relatively scarce.
Buhari Lawan Muhammad, Yoseph Seo, Jang-Seu Ki   +2 more
doaj   +1 more source

Heterogeneity of Pumpkin Ribosomal DNA [PDF]

Plant Physiology, 1983
The ribosomal DNA (rDNA) of Cucurbita pepo L. has been found to consist of tandemly arrayed repeat units, most of which are 10 kilobases in length. Thirty-six repeat units, cloned into the HindIII site of pACYC 177, fall into seven classes which differ from each other in length and/or nucleotide sequence.
A, Siegel, K, Kolacz
openaire   +2 more sources

Ribosomal DNA heterochromatin in plants [PDF]

Cytogenetic and Genome Research, 2005
The aim of this review is to integrate earlier results and recent findings to present the current state-of-the-art vision concerning the dynamic behavior of the ribosomal DNA (rDNA) fraction in plants. The global organization and behavioral features of rDNA make it a most useful system to analyse the relationship between chromatin topology and gene ...
Neves, N., Delgado, M., Silva, M., Caperta, A., Morais-Cecilio, L., Viegas, W.   +5 more
openaire   +3 more sources

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer.

Cell Stem Cell, 2020
Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes and phenotypes. Here, we reveal a previously unappreciated heterogeneity in the biosynthetic capacities of CRC cells.
Clara Morral, Jelena Stanisavljević, Xavier Hernando-Momblona, E. Mereu, A. Álvarez-Varela, C. Cortina, Diana Stork, Felipe Slebe, Gemma Turon, Gavin Whissell, Marta Sevillano, A. Merlos-Suárez, À. Casanova-Martí, C. Moutinho, S. Lowe, L. Dow, A. Villanueva, E. Sancho, H. Heyn, E. Batlle   +19 more
semanticscholar   +1 more source

Ribosomal DNA-connecting ribosome biogenesis and chromosome biology [PDF]

Chromosome Research, 2019
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome.
Lev, Porokhovnik, Jennifer L, Gerton
openaire   +2 more sources

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase

BMC Cell Biology, 2003
Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The
Paric Enesa, Schawalder James, Neff Norma F   +2 more
doaj   +1 more source

Recognition of Ribosomal RNA Sites in DNA, I. Analysis of the E. coli System [PDF]

, 1965
The evidence recently presented of specific hybridization between bacterial ribosomal RNA and homologous DNA1-3 has indicated the possibility of a biochemical approach to the problem of the identification of ribosomal RNA sites in DNA.
Attardi, Giuseppe, Huang, Pien Chien, Kabat, Susan   +2 more
core   +1 more source