Results 1 to 10 of about 2,865,359 (294)

Continuously tunable nucleic acid hybridization probes. [PDF]

Nat Methods, 2015
In silico-designed nucleic acid probes and primers often do not achieve favorable specificity and sensitivity tradeoffs on the first try, and iterative empirical sequence-based optimization is needed, particularly in multiplexed assays. We present a novel, on-the-fly method of tuning probe affinity and selectivity by adjusting the stoichiometry of ...
Wu LR, Wang JS, Fang JZ, Evans ER, Pinto A, Pekker I, Boykin R, Ngouenet C, Webster PJ, Beechem J, Zhang DY.   +10 more
europepmc   +5 more sources

Peptide‐Peptide Nucleic Acid Hybrid Hydrogel Based on Sequence Programmable Morphological Change for DNA Data Storage

Small Structures
Peptide‐based hydrogels provide biocompatible, stimuli‐responsive platforms, while peptide‐DNA hybrids extend programmability through hybridization‐driven crosslinking. However, nucleobase incorporation can influence peptide self‐assembly pathways.
Huiling Lei, Jinsheng Li, Zixiao Zhang, Zi’an Lin, Guangxu Zhang, Jianjian Huang, Shuhan Dai, Guojiao Wu, Hongmei Liu, Yuzhou Wu   +9 more
doaj   +1 more source

Label-Free Detection of Zeptomol miRNA via Peptide Nucleic Acid Hybridization Using Novel Cyclic Voltammetry Method. [PDF]

Sensors (Basel), 2020
Takase S, Miyagawa K, Ikeda H.
europepmc   +1 more source

In-situ dual-lighting system for HER2 nucleic acid and protein co-localization through simultaneous visual signal amplification in single pathological sections

Communications Medicine
Background The pathological state of human epidermal growth factor receptor-2 (HER2) determines the treatment strategies. Immunohistochemistry (IHC) and in situ hybridization (ISH) are the only two recognized diagnostic methods for HER2-positive (HER2 + )
Tiantian Wang, Zhiqing Chen, Xuan Fu, Lin Chen, Yao Huang, Ang Liu, Qingling Zhang, Bei Hu, Weiyang Liang, Qunyue Wu, Shan Li, Xin Li, Lei Zhang   +12 more
doaj   +1 more source

The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization. [PDF]

J Am Chem Soc, 2018
Fong LK, Wang Z, Schatz GC, Luijten E, Mirkin CA.   +4 more
europepmc   +1 more source

Enzyme fragment complementation driven by nucleic acid hybridization sans self-labeling protein. [PDF]

Bioorg Chem
Xu Z, Zhang X, Pal C, Rozners E, Callahan BP.   +4 more
europepmc   +1 more source

Visualized Nucleic Acid Hybridization Lateral Flow Strip Integrating with Microneedle for the Point-of-Care Authentication of Ophiocordyceps sinensis. [PDF]

Int J Mol Sci
Liu H, Wang X, Tian H, Yuan Y, Wang J, Cheng Y, Sun L, Chen H, Song X.   +8 more
europepmc   +1 more source

Nucleic acid hybridization-based detection of pathogenic RNA using microscale thermophoresis. [PDF]

J Biol Chem
Avivi MY, Touitou N, Rohana H, Lerrer B, Shav-Tal Y, Peretz A, Cohen HY.   +6 more
europepmc   +1 more source

The Use of Atomic Force Microscopy for 3D Analysis of Nucleic Acid Hybridization on Microarrays. [PDF]

Acta Naturae, 2015
Dubrovin EV, Presnova GV, Rubtsova MY, Egorov AM, Grigorenko VG, Yaminsky IV.   +5 more
europepmc   +1 more source

Cross-platform comparison of nucleic acid hybridization: toward quantitative reference standards. [PDF]

Anal Biochem, 2014
Halvorsen K, Agris PF.
europepmc   +1 more source