Results 11 to 20 of about 471,867 (378)

Diagnostics based on nucleic acid sequence variant profiling: PCR, hybridization, and NGS approaches.

Advanced Drug Delivery Reviews, 2016
Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine.
Dmitriy A. Khodakov, Chunyan Wang, D. Zhang   +2 more
semanticscholar   +3 more sources

Colorimetric Detection of Ehrlichia Canis via Nucleic Acid Hybridization in Gold Nano-Colloids [PDF]

Sensors, 2014
Canine monocytic ehrlichiosis (CME) is a major thick-bone disease of dog caused by Ehrlichia canis. Detection of this causal agent outside the laboratory using conventional methods is not effective enough. Thus an assay for E.
Ajima Muangchuen, Piyasak Chaumpluk, Annop Suriyasomboon, Sanong Ekgasit   +3 more
doaj   +2 more sources

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay. [PDF]

Nucleic Acid Ther, 2017
Godinho BMDC, Gilbert JW, Haraszti RA, Coles AH, Biscans A, Roux L, Nikan M, Echeverria D, Hassler M, Khvorova A.   +9 more
europepmc   +2 more sources

The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization*

Spherical Nucleic Acids, 2020
Lam-Kiu Fong, Ziwei Wang, George C. Schatz, Erik Luijten, Chad A. Mirkina   +4 more
openalex   +3 more sources

Enzyme fragment complementation driven by nucleic acid hybridization sans self-labeling protein. [PDF]

Bioorg Chem
Xu Z, Zhang X, Pal C, Rozners E, Callahan BP.   +4 more
europepmc   +3 more sources

In-situ dual-lighting system for HER2 nucleic acid and protein co-localization through simultaneous visual signal amplification in single pathological sections [PDF]

Communications Medicine
Background The pathological state of human epidermal growth factor receptor-2 (HER2) determines the treatment strategies. Immunohistochemistry (IHC) and in situ hybridization (ISH) are the only two recognized diagnostic methods for HER2-positive (HER2 + )
Tiantian Wang, Zhiqing Chen, Xuan Fu, Lin Chen, Yao Huang, Ang Liu, Qingling Zhang, Bei Hu, Weiyang Liang, Qunyue Wu, Shan Li, Xin Li, Lei Zhang   +12 more
doaj   +2 more sources

Mfold web server for nucleic acid folding and hybridization prediction

Nucleic Acids Research, 2003
M. Zuker
semanticscholar   +3 more sources

Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood

Nature Nanotechnology, 2018
Roya Tavallaie, Joshua A. McCarroll, Marion Le Grand, Nicholas Ariotti, Wolfgang Schuhmann, Eric Bakker, Richard D. Tilley, David Brynn Hibbert, Maria Kavallaris, J. Justin Gooding   +9 more
openalex   +3 more sources

Nucleic acid amphiphiles: Synthesis, properties, and applications

Molecular Therapy: Nucleic Acids, 2023
Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles ...
Amu Gubu, Xueli Zhang, Aiping Lu, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
doaj   +1 more source

Fast and non-toxic in situ hybridization without blocking of repetitive sequences. [PDF]

PLoS ONE, 2012
Formamide is the preferred solvent to lower the melting point and annealing temperature of nucleic acid strands in in situ hybridization (ISH). A key benefit of formamide is better preservation of morphology due to a lower incubation temperature. However,
Steen H Matthiesen, Charles M Hansen
doaj   +1 more source